Tyrosine-protein kinase HCK

BE0001424ProteinHumansHCK

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis,... It is acted on by 8 drugs in DrugBank.

Gene name
HCK
UniProtKB entry
P08631Swiss-Prot
Cellular location
Lysosome
Residues / weight
526 residues · 59,599 Da
Also known as
2.7.10.2 · Hematopoietic cell kinase · Hemopoietic cell kinase · p59-HCK/p60-HCK · p59Hck

Resolves to

Protein
UniProtP08631UniProt nameHCK_HUMAN
Gene
HGNCHGNC:4840NCBI Gene3055GenBank306832GeneCardsHCK
Pharmacology
IUPHAR/GtoPdb2032KEGGhsa:3055
Structure
PDB1AD5PDB1BU1PDB1QCF
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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70+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase HCK, how selective are they, and which programs against it are still in active trials?

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