DNA repair protein XRCC4

BE0001585ProteinHumansXRCC4

DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). It is acted on by 1 drug in DrugBank.

Gene name
XRCC4
UniProtKB entry
Q13426Swiss-Prot
Cellular location
Nucleus
Residues / weight
336 residues · 38,286 Da
Also known as
hXRCC4 · X-ray repair cross-complementing protein 4

Resolves to

Protein
UniProtQ13426UniProt nameXRCC4_HUMAN
Gene
HGNCHGNC:12831NCBI Gene7518GenBank1151115GeneCardsXRCC4
Pharmacology
KEGGhsa:7518
Structure
PDB1FU1PDB1IK9PDB3II6
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA repair protein XRCC4, and which indications are they being tested in?

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