Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
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Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.
- PubMed ID
- 20068231 [ View in PubMed]
- Abstract
Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are tightly regulated at defined stages of the cell division cycle. Progression through this cycle involves a large number of dedicated protein complexes and signaling pathways, and deregulation of this process is implicated in tumorigenesis. We applied high-resolution mass spectrometry-based proteomics to investigate the proteome and phosphoproteome of the human cell cycle on a global scale and quantified 6027 proteins and 20,443 unique phosphorylation sites and their dynamics. Co-regulated proteins and phosphorylation sites were grouped according to their cell cycle kinetics and compared to publicly available messenger RNA microarray data. Most detected phosphorylation sites and more than 20% of all quantified proteins showed substantial regulation, mainly in mitotic cells. Kinase-motif analysis revealed global activation during S phase of the DNA damage response network, which was mediated by phosphorylation by ATM or ATR or DNA-dependent protein kinases. We determined site-specific stoichiometry of more than 5000 sites and found that most of the up-regulated sites phosphorylated by cyclin-dependent kinase 1 (CDK1) or CDK2 were almost fully phosphorylated in mitotic cells. In particular, nuclear proteins and proteins involved in regulating metabolic processes have high phosphorylation site occupancy in mitosis. This suggests that these proteins may be inactivated by phosphorylation in mitotic cells.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial P56181 Details 7-dehydrocholesterol reductase Q9UBM7 Details RAF proto-oncogene serine/threonine-protein kinase P04049 Details Transketolase P29401 Details L-lactate dehydrogenase B chain P07195 Details Creatine kinase B-type P12277 Details Pyruvate kinase PKM P14618 Details L-lactate dehydrogenase C chain P07864 Details Glutamate--cysteine ligase catalytic subunit P48506 Details DNA ligase 3 P49916 Details Carnitine O-palmitoyltransferase 2, mitochondrial P23786 Details Bifunctional glutamate/proline--tRNA ligase P07814 Details DNA ligase 1 P18858 Details Large neutral amino acids transporter small subunit 1 Q01650 Details Pyrroline-5-carboxylate reductase 1, mitochondrial P32322 Details Tryptophan--tRNA ligase, cytoplasmic P23381 Details Neutral amino acid transporter B(0) Q15758 Details 5'-AMP-activated protein kinase subunit beta-1 Q9Y478 Details Beta-1,4-galactosyltransferase 1 P15291 Details Alanine--tRNA ligase, cytoplasmic P49588 Details GMP synthase [glutamine-hydrolyzing] P49915 Details Acetyl-coenzyme A synthetase, cytoplasmic Q9NR19 Details Sodium- and chloride-dependent creatine transporter 1 P48029 Details Ferritin heavy chain P02794 Details Retinoic acid receptor RXR-alpha P19793 Details Annexin A1 P04083 Details Serine/threonine-protein kinase A-Raf P10398 Details Tyrosine-protein kinase ABL2 P42684 Details Monocarboxylate transporter 4 O15427 Details Neutral amino acid transporter A P43007 Details Isoleucine--tRNA ligase, cytoplasmic P41252 Details Receptor tyrosine-protein kinase erbB-2 P04626 Details Aspartyl/asparaginyl beta-hydroxylase Q12797 Details Chromodomain-helicase-DNA-binding protein 1 O14646 Details Glyceraldehyde-3-phosphate dehydrogenase P04406 Details Methionine--tRNA ligase, cytoplasmic P56192 Details DNA polymerase alpha catalytic subunit P09884 Details Cationic amino acid transporter 2 P52569 Details Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 Details Malate dehydrogenase, cytoplasmic P40925 Details Solute carrier family 12 member 4 Q9UP95 Details Asparagine--tRNA ligase, cytoplasmic O43776 Details Choline-phosphate cytidylyltransferase A P49585 Details Tyrosine-protein phosphatase non-receptor type 1 P18031 Details Acetyl-CoA carboxylase 1 Q13085 Details Serine/threonine-protein kinase B-raf P15056 Details UDP-glucose 6-dehydrogenase O60701 Details Cytosolic phospholipase A2 P47712 Details Monocarboxylate transporter 1 P53985 Details Argininosuccinate synthase P00966 Details 5'-AMP-activated protein kinase catalytic subunit alpha-1 Q13131 Details Retinoic acid-induced protein 3 Q8NFJ5 Details Cysteine--tRNA ligase, cytoplasmic P49589 Details DNA polymerase alpha subunit B Q14181 Details Inosine-5'-monophosphate dehydrogenase 2 P12268 Details Pyrroline-5-carboxylate reductase 2 Q96C36 Details Heme oxygenase 1 P09601 Details DNA topoisomerase 2-alpha P11388 Details Sodium/hydrogen exchanger 1 P19634 Details Thromboxane A2 receptor P21731 Details Methionine synthase reductase Q9UBK8 Details Epidermal growth factor receptor P00533 Details 5'-AMP-activated protein kinase subunit beta-2 O43741 Details Sphingosine-1-phosphate lyase 1 O95470 Details Multidrug resistance-associated protein 1 P33527 Details Glucocorticoid receptor P04150 Details Tyrosine-protein kinase Fyn P06241 Details Ephrin type-A receptor 2 P29317 Details Perilipin-3 O60664 Details Insulin-like growth factor 1 receptor P08069 Details CTP synthase 1 P17812 Details Signal transducer and activator of transcription 5B P51692 Details DNA (cytosine-5)-methyltransferase 1 P26358 Details Calpastatin P20810 Details C-X-C chemokine receptor type 4 P61073 Details Mitogen-activated protein kinase 1 P28482 Details Fatty acid synthase P49327 Details DNA topoisomerase 1 P11387 Details Catenin beta-1 P35222 Details Calnexin P27824 Details Peptidyl-prolyl cis-trans isomerase A P62937 Details Mitogen-activated protein kinase 14 Q16539 Details Transcription factor Jun P05412 Details Proton-coupled folate transporter Q96NT5 Details Solute carrier family 2, facilitated glucose transporter member 1 P11166 Details Mitogen-activated protein kinase 3 P27361 Details Glycogen synthase kinase-3 beta P49841 Details ATP-binding cassette sub-family C member 2 Q92887 Details Tyrosine-protein phosphatase non-receptor type 11 Q06124 Details Cyclin-dependent kinase 1 P06493 Details Intercellular adhesion molecule 1 P05362 Details Endoplasmic reticulum chaperone BiP P11021 Details Phosphatidylserine synthase 1 P48651 Details CD44 antigen P16070 Details Heat shock protein HSP 90-alpha P07900 Details Protein kinase C alpha type P17252 Details Deoxyhypusine synthase P49366 Details Inhibitor of nuclear factor kappa-B kinase subunit beta O14920 Details Endoplasmin P14625 Details Microtubule-associated protein 1A P78559 Details 14-3-3 protein zeta/delta P63104 Details Phosphatidylethanolamine-binding protein 1 P30086 Details ATP-binding cassette sub-family C member 4 O15439 Details Cystic fibrosis transmembrane conductance regulator P13569 Details Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial P33316 Details Casein kinase II subunit alpha P68400 Details Thymidine kinase, cytosolic P04183 Details 3',5'-cyclic-AMP phosphodiesterase 4D Q08499 Details Tubulin alpha-1C chain Q9BQE3 Details Methionine aminopeptidase 2 P50579 Details DNA repair protein XRCC4 Q13426 Details Fructose-bisphosphate aldolase A P04075 Details Ras-related protein Rab-9A P51151 Details Poly [ADP-ribose] polymerase 1 P09874 Details Early endosome antigen 1 Q15075 Details Kinesin-like protein KIF11 P52732 Details Heat shock protein HSP 90-beta P08238 Details Cyclin-dependent kinase 7 P50613 Details ADP-ribose pyrophosphatase, mitochondrial Q9BW91 Details Keratin, type II cytoskeletal 8 P05787 Details Retinoblastoma-associated protein P06400 Details Pyridoxal-dependent decarboxylase domain-containing protein 1 Q6P996 Details Molybdenum cofactor sulfurase Q96EN8 Details Cyanocobalamin reductase / alkylcobalamin dealkylase Q9Y4U1 Details Choline/ethanolaminephosphotransferase 1 Q9Y6K0 Details Egl nine homolog 1 Q9GZT9 Details Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase P22234 Details Multifunctional protein CAD P27708 Details Phosphoribosylformylglycinamidine synthase O15067 Details Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial P55809 Details N-acetyl-D-glucosamine kinase Q9UJ70 Details Phosphatidylserine synthase 2 Q9BVG9 Details Retinol dehydrogenase 14 Q9HBH5 Details Peptidyl-prolyl cis-trans isomerase G Q13427 Details Proteasome subunit beta type-2 P49721 Details Histone deacetylase 1 Q13547 Details Histone deacetylase 2 Q92769 Details Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 Details Phosphatidylinositol 3-kinase regulatory subunit beta O00459 Details DNA-dependent protein kinase catalytic subunit P78527 Details Serine/threonine-protein kinase mTOR P42345 Details Nuclear factor NF-kappa-B p100 subunit Q00653 Details Superoxide dismutase [Cu-Zn] P00441 Details NF-kappa-B essential modulator Q9Y6K9 Details Protein kinase C delta type Q05655 Details DNA topoisomerase 2-beta Q02880 Details Ribonucleoside-diphosphate reductase subunit M2 P31350 Details E3 ubiquitin-protein ligase UBR4 Q5T4S7 Details NAD-dependent protein deacetylase sirtuin-1 Q96EB6 Details Non-selective voltage-gated ion channel VDAC1 P21796 Details Voltage-dependent anion-selective channel protein 2 P45880 Details N-terminal kinase-like protein Q96KG9 Details Prostaglandin E synthase 3 Q15185 Details Gephyrin Q9NQX3 Details U1 small nuclear ribonucleoprotein A P09012 Details Protein S100-A11 P31949 Details Deoxycytidine kinase P27707 Details Mismatch repair endonuclease PMS2 P54278 Details Focal adhesion kinase 1 Q05397 Details Wee1-like protein kinase P30291 Details Serine/threonine-protein kinase Chk1 O14757 Details Aurora kinase B Q96GD4 Details Bcl-2-like protein 2 Q92843 Details Far upstream element-binding protein 1 Q96AE4 Details cAMP-dependent protein kinase type II-alpha regulatory subunit P13861 Details cAMP-dependent protein kinase type I-alpha regulatory subunit P10644 Details High mobility group protein B1 P09429 Details Heat shock protein beta-1 P04792 Details Signal transducer and activator of transcription 3 P40763 Details Ribosome-binding protein 1 Q9P2E9 Details Microtubule-associated protein 4 P27816 Details Heat shock factor protein 1 Q00613 Details Histone deacetylase 4 P56524 Details Histone deacetylase 7 Q8WUI4 Details DNA polymerase epsilon catalytic subunit A Q07864 Details DNA polymerase epsilon subunit 4 Q9NR33 Details DNA polymerase epsilon subunit 3 Q9NRF9 Details Cation-independent mannose-6-phosphate receptor P11717 Details ATP-binding cassette sub-family C member 5 O15440 Details Solute carrier organic anion transporter family member 4A1 Q96BD0 Details Copper-transporting ATPase 1 Q04656 Details High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A O60658 Details High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B O95263 Details Nuclear receptor coactivator 1 Q15788 Details Guanine nucleotide-binding protein G(s) subunit alpha isoforms short P63092 Details Nuclear receptor coactivator 2 Q15596 Details Serine/threonine-protein kinase PLK1 P53350 Details Disintegrin and metalloproteinase domain-containing protein 17 P78536 Details S-phase kinase-associated protein 1 P63208 Details Uracil-DNA glycosylase P13051 Details BAG family molecular chaperone regulator 1 Q99933 Details Heat shock cognate 71 kDa protein P11142 Details Dual specificity protein kinase TTK P33981 Details Inner centromere protein Q9NQS7 Details Serine/threonine-protein phosphatase PP1-alpha catalytic subunit P62136 Details Large ribosomal subunit protein uL23 P62750 Details Large ribosomal subunit protein eL37 P61927 Details Large ribosomal subunit protein uL3 P39023 Details Triosephosphate isomerase P60174 Details Cytosol aminopeptidase P28838 Details Protein kinase C iota type P41743 Details Proteasome subunit alpha type-3 P25788 Details Proteasome subunit alpha type-4 P25789 Details Proteasome subunit alpha type-5 P28066 Details Proteasome subunit beta type-7 Q99436 Details Casein kinase I isoform gamma-3 Q9Y6M4 Details STE20-like serine/threonine-protein kinase Q9H2G2 Details Dual specificity protein kinase CLK3 P49761 Details Nuclear receptor coactivator 5 Q9HCD5 Details Hydroxymethylglutaryl-CoA synthase, cytoplasmic Q01581 Details Geranylgeranyl transferase type-2 subunit beta P53611 Details Cyclin-dependent kinase 16 Q00536 Details Serine/threonine-protein kinase Sgk1 O00141 Details Serine/threonine-protein kinase 26 Q9P289 Details Myocardin-related transcription factor A Q969V6 Details Destrin P60981 Details Cofilin-1 P23528 Details Rho-associated protein kinase 2 O75116 Details Actin-related protein 2/3 complex subunit 1B O15143 Details Ribosomal protein S6 kinase alpha-1 Q15418 Details Elongation factor 2 P13639 Details Tyrosine-protein kinase Lyn P07948 Details SRSF protein kinase 2 P78362 Details Glycylpeptide N-tetradecanoyltransferase 1 P30419 Details Afadin P55196 Details Interleukin-1 receptor-associated kinase 4 Q9NWZ3 Details CREB-binding protein Q92793 Details Mediator of RNA polymerase II transcription subunit 1 Q15648 Details Calcium/calmodulin-dependent protein kinase type II subunit gamma Q13555 Details Mothers against decapentaplegic homolog 2 Q15796 Details Protein arginine N-methyltransferase 3 O60678 Details Epsin-1 Q9Y6I3 Details Phosphoglycerate kinase 1 P00558 Details Phosphoglucomutase-1 P36871 Details Vimentin P08670 Details Uridine 5'-monophosphate synthase P11172 Details Acyl-CoA-binding protein P07108 Details Ras-related protein Rab-7a P51149 Details Aconitate hydratase, mitochondrial Q99798 Details Poly(A) polymerase alpha P51003 Details 6-pyruvoyl tetrahydrobiopterin synthase Q03393 Details Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Q14643 Details Unconventional myosin-Ie Q12965 Details Gamma-enolase P09104 Details 14-3-3 protein epsilon P62258 Details Branched-chain alpha-ketoacid dehydrogenase kinase O14874 Details Transitional endoplasmic reticulum ATPase P55072 Details Ubiquitin-like modifier-activating enzyme 1 P22314 Details Sorting nexin-3 O60493 Details SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 O60264 Details Uridine-cytidine kinase-like 1 Q9NWZ5 Details Spectrin beta chain, non-erythrocytic 1 Q01082 Details Spliceosome RNA helicase DDX39B Q13838 Details Selenocysteine lyase Q96I15 Details Ribosomal protein S6 kinase alpha-4 O75676 Details Kinesin-like protein KIF2C Q99661 Details Transient receptor potential cation channel subfamily M member 7 Q96QT4 Details Hepatocyte growth factor-regulated tyrosine kinase substrate O14964 Details Serine/threonine-protein kinase TAO2 Q9UL54 Details ADP-ribosylation factor-like protein 3 P36405 Details Peroxiredoxin-6 P30041 Details Sodium bicarbonate cotransporter 3 Q9Y6M7 Details Myc proto-oncogene protein P01106 Details Equilibrative nucleoside transporter 2 Q14542 Details Reduced folate transporter P41440 Details Dual specificity mitogen-activated protein kinase kinase 2 P36507 Details Mitogen-activated protein kinase kinase kinase 2 Q9Y2U5 Details Transferrin receptor protein 1 P02786 Details Ribosomal protein S6 kinase alpha-3 P51812 Details Membrane-associated progesterone receptor component 1 O00264 Details Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 Q14573 Details Cyclic AMP-dependent transcription factor ATF-1 P18846 Details Cyclic AMP-dependent transcription factor ATF-2 P15336 Details Cyclic AMP-dependent transcription factor ATF-4 P18848 Details Intracellular hyaluronan-binding protein 4 Q5JVS0 Details Histone H1.4 P10412 Details Casein kinase II subunit beta P67870 Details Mitogen-activated protein kinase kinase kinase 20 Q9NYL2 Details Dihydropyrimidinase-related protein 2 Q16555 Details Alpha-enolase P06733 Details Protein PML P29590 Details Nucleolar and coiled-body phosphoprotein 1 Q14978 Details TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 Details Protein O-GlcNAcase O60502 Details Utrophin P46939 Details Proprotein convertase subtilisin/kexin type 9 Q8NBP7 Details Sodium-dependent phosphate transporter 2 Q08357 Details Translationally-controlled tumor protein P13693 Details Nucleobindin-2 P80303 Details Protein S100-A16 Q96FQ6 Details 60 kDa heat shock protein, mitochondrial P10809 Details Small ribosomal subunit protein uS5 P15880 Details Heterogeneous nuclear ribonucleoproteins A2/B1 P22626 Details Heterogeneous nuclear ribonucleoprotein H P31943 Details Heterogeneous nuclear ribonucleoprotein H3 P31942 Details Heterogeneous nuclear ribonucleoprotein L P14866 Details Splicing factor, proline- and glutamine-rich P23246 Details Stress-induced-phosphoprotein 1 P31948 Details Eukaryotic translation initiation factor 6 P56537 Details Hepatoma-derived growth factor P51858 Details Phosphoglycerate mutase 1 P18669 Details Ran-specific GTPase-activating protein P43487 Details Protein S100-A9 P06702 Details Huntingtin P42858 Details Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Q8N1G2 Details Neural cell adhesion molecule L1 P32004 Details Flap endonuclease 1 P39748 Details Eukaryotic translation initiation factor 3 subunit F O00303 Details Heterogeneous nuclear ribonucleoprotein F P52597 Details Heterogeneous nuclear ribonucleoprotein K P61978 Details 10 kDa heat shock protein, mitochondrial P61604 Details Heat shock protein 105 kDa Q92598 Details Nuclear migration protein nudC Q9Y266 Details 26S proteasome regulatory subunit 6A P17980 Details SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Q969G3 Details Tumor protein D54 O43399 Details Ubiquitin carboxyl-terminal hydrolase 14 P54578 Details 14-3-3 protein theta P27348 Details Chromobox protein homolog 5 P45973 Details Keratin, type II cytoskeletal 1 P04264 Details Desmoplakin P15924 Details Hornerin Q86YZ3 Details Junction plakoglobin P14923 Details Far upstream element-binding protein 2 Q92945 Details Cysteine and glycine-rich protein 1 P21291 Details Filamin-A P21333 Details Heterogeneous nuclear ribonucleoprotein D0 Q14103 Details Heterochromatin protein 1-binding protein 3 Q5SSJ5 Details Ras GTPase-activating-like protein IQGAP1 P46940 Details Nucleophosmin P06748 Details Large ribosomal subunit protein eL14 P50914 Details Large ribosomal subunit protein eL18 Q07020 Details Large ribosomal subunit protein uL4 P36578 Details Small ribosomal subunit protein eS17 P08708 Details Small ribosomal subunit protein eS6 P62753 Details Splicing factor 1 Q15637 Details Small nuclear ribonucleoprotein Sm D2 P62316 Details Serine/arginine-rich splicing factor 4 Q08170 Details Transgelin-2 P37802 Details Zyxin Q15942 Details Serine/arginine-rich splicing factor 1 Q07955 Details Survival motor neuron protein B4DP61 Details Myosin-9 P35579 Details Probable ATP-dependent RNA helicase DDX5 P17844 Details Splicing factor 3B subunit 1 O75533 Details Very long chain fatty acid elongase 5 Q9NYP7 Details Serine/threonine-protein kinase 24 Q9Y6E0 Details Serine/threonine-protein kinase 38 Q15208 Details Serine/threonine-protein kinase 38-like Q9Y2H1 Details STE20/SPS1-related proline-alanine-rich protein kinase Q9UEW8 Details Serine/threonine-protein kinase TAO3 Q9H2K8 Details Serine/threonine-protein kinase tousled-like 1 Q9UKI8 Details Non-receptor tyrosine-protein kinase TNK1 Q13470 Details Serine/threonine-protein kinase ULK1 O75385 Details AP2-associated protein kinase 1 Q2M2I8 Details BMP-2-inducible protein kinase Q9NSY1 Details Calcium/calmodulin-dependent protein kinase kinase 1 Q8N5S9 Details Citron Rho-interacting kinase O14578 Details Casein kinase I isoform alpha P48729 Details Interferon-induced, double-stranded RNA-activated protein kinase P19525 Details eIF-2-alpha kinase GCN2 Q9P2K8 Details Dual specificity mitogen-activated protein kinase kinase 3 P46734 Details Mitogen-activated protein kinase kinase kinase kinase 4 O95819 Details Serine/threonine-protein kinase MARK2 Q7KZI7 Details CLIP-associating protein 1 Q7Z460 Details Misshapen-like kinase 1 Q8N4C8 Details Serine/threonine-protein kinase Nek9 Q8TD19 Details Serine/threonine-protein kinase OSR1 O95747 Details Serine/threonine-protein kinase PAK 2 Q13177 Details Serine/threonine-protein kinase PAK 4 O96013 Details Phosphatidylinositol 4-kinase beta Q9UBF8 Details Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Q99640 Details Serine/threonine-protein kinase N1 Q16512 Details Serine/threonine-protein kinase N2 Q16513 Details Serine/threonine-protein kinase PRP4 homolog Q13523 Details Serine/threonine-protein kinase RIO1 Q9BRS2 Details Serine/threonine-protein kinase RIO2 Q9BVS4 Details Receptor-interacting serine/threonine-protein kinase 2 O43353 Details Serine/threonine-protein kinase 10 O94804 Details Intestinal-type alkaline phosphatase P09923 Details Histone-lysine N-methyltransferase EZH2 Q15910 Details Exportin-1 O14980 Details POU domain, class 2, transcription factor 1 P14859 Details Dystrophin P11532 Details Equilibrative nucleobase transporter 1 Q8NBI5 Details Plasma membrane ascorbate-dependent reductase CYBRD1 Q53TN4 Details ATP-citrate synthase P53396 Details Long-chain fatty acid transport protein 2 O14975 Details Sodium-coupled neutral amino acid symporter 1 Q9H2H9 Details Sodium-coupled neutral amino acid symporter 2 Q96QD8 Details DNA (cytosine-5)-methyltransferase 3A Q9Y6K1 Details Zinc transporter SLC39A7 Q92504 Details Proton-coupled zinc antiporter SLC30A5 Q8TAD4 Details Zinc transporter ZIP3 Q9BRY0 Details Tyrosine-protein phosphatase non-receptor type 12 Q05209 Details V-type proton ATPase 116 kDa subunit a 4 Q9HBG4 Details Caspase-4 P49662 Details Plasma membrane calcium-transporting ATPase 1 P20020 Details Caspase-9 P55211 Details DNA (cytosine-5)-methyltransferase 3B Q9UBC3 Details Interleukin-6 receptor subunit beta P40189 Details Molybdopterin synthase catalytic subunit O96007 Details Receptor protein-tyrosine kinase Q504U8 Details Microphthalmia-associated transcription factor O75030 Details Eukaryotic translation initiation factor 4E-binding protein 1 Q13541 Details Lysine-specific histone demethylase 1A O60341 Details Signal transducer and activator of transcription 1-alpha/beta P42224 Details Proliferation marker protein Ki-67 P46013 Details ELAV-like protein 1 Q15717 Details Nuclear factor erythroid 2-related factor 2 Q16236 Details Dual specificity mitogen-activated protein kinase kinase 4 P45985 Details Adenylate cyclase type 9 O60503 Details