Tyrosine--tRNA ligase

BE0002031ProteinEscherichia coli (strain K12)tyrS

Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (PubMed:4292198, PubMed:4579631). It is acted on by 2 drugs in DrugBank.

Gene name
tyrS
UniProtKB entry
P0AGJ9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
424 residues · 47,527 Da
Also known as
6.1.1.1 · Tyrosyl-tRNA synthetase · TyrRS

Resolves to

Protein
UniProtP0AGJ9UniProt nameSYY_ECOLI
Gene
NCBI Gene948855GenBank148094
Pharmacology
KEGGecj:JW1629
Structure
PDB1VBMPDB1VBNPDB1WQ3
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tyrosine--tRNA ligase, and which indications are they being tested in?

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