Fibroblast growth factor receptor 3

BE0002133ProteinHumansFGFR3

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. It is acted on by 29 drugs in DrugBank.

Gene name
FGFR3
UniProtKB entry
P22607Swiss-Prot
Cellular location
Cell membrane
Residues / weight
806 residues · 87,709 Da
Also known as
2.7.10.1 · FGFR-3 · JTK4

Resolves to

Protein
UniProtP22607UniProt nameFGFR3_HUMAN
Gene
HGNCHGNC:3690NCBI Gene2261GenBank182569GeneCardsFGFR3
Pharmacology
IUPHAR/GtoPdb1810KEGGhsa:2261
Structure
PDB1RY7PDB2LZLPDB4K33
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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131+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fibroblast growth factor receptor 3, how selective are they, and which programs against it are still in active trials?

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