Egl nine homolog 1

BE0002217ProteinHumansEGLN1

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It is acted on by 19 drugs in DrugBank.

Gene name
EGLN1
UniProtKB entry
Q9GZT9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
426 residues · 46,021 Da
Also known as
1.14.11.29 · C1orf12 · HIF-PH2 · HIF-prolyl hydroxylase 2 · HPH-2

Resolves to

Protein
UniProtQ9GZT9UniProt nameEGLN1_HUMAN
Gene
HGNCHGNC:1232NCBI Gene54583GenBank11345052GeneCardsEGLN1
Pharmacology
IUPHAR/GtoPdb2833KEGGhsa:54583
Structure
PDB2G19PDB2G1MPDB2HBT
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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82+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Egl nine homolog 1, how selective are they, and which programs against it are still in active trials?

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