Voltage-dependent L-type calcium channel subunit alpha-1S

BE0002355ProteinHumansCACNA1S

Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. It is acted on by 14 drugs in DrugBank.

Gene name
CACNA1S
UniProtKB entry
Q13698Swiss-Prot
Cellular location
Cell membrane, sarcolemma, T-tubule
Residues / weight
1,873 residues · 212,348 Da
Also known as
CACH1 · CACN1 · CACNL1A3 · Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle · Voltage-gated calcium channel subunit alpha Cav1.1

Resolves to

Protein
UniProtQ13698UniProt nameCAC1S_HUMAN
Gene
HGNCHGNC:1397NCBI Gene779GenBank1698403GeneCardsCACNA1S
Pharmacology
IUPHAR/GtoPdb528KEGGhsa:779
Structure
PDB2VAYPDB6B27
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
36+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Voltage-dependent L-type calcium channel subunit alpha-1S, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In