ATP-binding cassette sub-family B member 5

BE0002369ProteinHumansABCB5

Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). It is acted on by 22 drugs in DrugBank.

Gene name
ABCB5
UniProtKB entry
Q2M3G0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,257 residues · 138,639 Da
Also known as
ABCB5 P-gp · P-glycoprotein ABCB5

Resolves to

Protein
UniProtQ2M3G0UniProt nameABCB5_HUMAN
Gene
HGNCHGNC:46NCBI Gene340273GeneCardsABCB5
Pharmacology
KEGGhsa:340273
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family B member 5, how selective are they, and which programs against it are still in active trials?

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