Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

BE0002379ProteinHumansPIK3CA

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). It is acted on by 19 drugs in DrugBank.

Gene name
PIK3CA
UniProtKB entry
P42336Swiss-Prot
Residues / weight
1,068 residues · 124,283 Da
Also known as
2.7.1.137 · 2.7.1.153 · p110alpha · Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha · Phosphoinositide 3-kinase alpha

Resolves to

Protein
UniProtP42336UniProt namePK3CA_HUMAN
Gene
HGNCHGNC:8975NCBI Gene5290GeneCardsPIK3CA
Pharmacology
IUPHAR/GtoPdb2153KEGGhsa:5290
Structure
PDB2ENQPDB2RD0PDB3HHM
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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31Clinical trialsTrials of drugs acting on it, by phase and status
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33GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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88+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, how selective are they, and which programs against it are still in active trials?

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