Wortmannin

DB08059ExperimentalSmall molecule

Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).

Mechanism: Pharmacologically active on Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Curator reviewed
Formula / weight: C₂₃H₂₄O₈ · 428.4319 g/mol (avg)
Also known as: Wartmannin
Code names: NSC-627609 · SL-2052

Resolves to

Compound

UNIIXVA4O219QWCAS19545-26-7ChEMBLCHEMBL428496ChEBI52289PubChem312145KEGGC15181

Structure

InChIKeyQDLHCMPXEPAAMD-QAIWCSMKSA-NSMILES[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)C2=C3C(=CO2)C(=O)O[C@H](COC)[C@]13C

Targets

P48736PIK3CGO00329PIK3CDP53350PLK1P27986PIK3R1P42336PIK3CA

What you can answer from here — as of January 29, 2025

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,035Drug interactionsStructured to mechanism, not free text

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Wortmannin, and which of those have an active Phase 3 trial?

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