Actin nucleation-promoting factor WAS

BE0002513ProteinHumansWAS

Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). It is acted on by 1 drug in DrugBank.

Gene name
WAS
UniProtKB entry
P42768Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
502 residues · 52,912 Da
Also known as
IMD2 · WASp · Wiskott-Aldrich syndrome protein

Resolves to

Protein
UniProtP42768UniProt nameWASP_HUMAN
Gene
HGNCHGNC:12731NCBI Gene7454GeneCardsWAS
Pharmacology
KEGGhsa:7454
Structure
PDB1CEEPDB1EJ5PDB1T84
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Actin nucleation-promoting factor WAS, and which indications are they being tested in?

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