Actin nucleation-promoting factor WAS
Details
- Name
- Actin nucleation-promoting factor WAS
- Kind
- protein
- Synonyms
- IMD2
- WASp
- Wiskott-Aldrich syndrome protein
- Gene Name
- WAS
- UniProtKB Entry
- P42768Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004935|Actin nucleation-promoting factor WAS MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL EAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPP PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA IHSSDEGEDQAGDEDEDDEWDD
- Number of residues
- 502
- Molecular Weight
- 52912.175
- Theoretical pI
- 6.61
- GO Classification
- Functionsactin binding / small GTPase bindingProcessesCdc42 protein signal transduction / cellular response to type II interferon / negative regulation of stress fiber assembly / positive regulation of double-strand break repair via homologous recombination / positive regulation of transcription by RNA polymerase II / protein-containing complex assembly / regulation of actin polymerization or depolymerization / regulation of lamellipodium assembly / regulation of stress fiber assemblyComponentsactin filament / nucleus / phagocytic vesicle / plasma membrane / site of double-strand break
- General Function
- Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)
- Specific Function
- actin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm, cytoskeleton
- Gene sequence
>lcl|BSEQ0021676|Wiskott-Aldrich syndrome protein (WAS) ATGAGTGGGGGCCCAATGGGAGGAAGGCCCGGGGGCCGAGGAGCACCAGCGGTTCAGCAG AACATACCCTCCACCCTCCTCCAGGACCACGAGAACCAGCGACTCTTTGAGATGCTTGGA CGAAAATGCTTGACGCTGGCCACTGCAGTTGTTCAGCTGTACCTGGCGCTGCCCCCTGGA GCTGAGCACTGGACCAAGGAGCATTGTGGGGCTGTGTGCTTCGTGAAGGATAACCCCCAG AAGTCCTACTTCATCCGCCTTTACGGCCTTCAGGCTGGTCGGCTGCTCTGGGAACAGGAG CTGTACTCACAGCTTGTCTACTCCACCCCCACCCCCTTCTTCCACACCTTCGCTGGAGAT GACTGCCAAGCGGGGCTGAACTTTGCAGACGAGGACGAGGCCCAGGCCTTCCGGGCCCTC GTGCAGGAGAAGATACAAAAAAGGAATCAGAGGCAAAGTGGAGACAGACGCCAGCTACCC CCACCACCAACACCAGCCAATGAAGAGAGAAGAGGAGGGCTCCCACCCCTGCCCCTGCAT CCAGGTGGAGACCAAGGAGGCCCTCCAGTGGGTCCGCTCTCCCTGGGGCTGGCGACAGTG GACATCCAGAACCCTGACATCACGAGTTCACGATACCGTGGGCTCCCAGCACCTGGACCT AGCCCAGCTGATAAGAAACGCTCAGGGAAGAAGAAGATCAGCAAAGCTGATATTGGTGCA CCCAGTGGATTCAAGCATGTCAGCCACGTGGGGTGGGACCCCCAGAATGGATTTGACGTG AACAACCTCGACCCAGATCTGCGGAGTCTGTTCTCCAGGGCAGGAATCAGCGAGGCCCAG CTCACCGACGCCGAGACCTCTAAACTTATCTACGACTTCATTGAGGACCAGGGTGGGCTG GAGGCTGTGCGGCAGGAGATGAGGCGCCAGGAGCCACTTCCGCCGCCCCCACCGCCATCT CGAGGAGGGAACCAGCTCCCCCGGCCCCCTATTGTGGGGGGTAACAAGGGTCGTTCTGGT CCACTGCCCCCTGTACCTTTGGGGATTGCCCCACCCCCACCAACACCCCGGGGACCCCCA CCCCCAGGCCGAGGGGGCCCTCCACCACCACCCCCTCCAGCTACTGGACGTTCTGGACCA CTGCCCCCTCCACCCCCTGGAGCTGGTGGGCCACCCATGCCACCACCACCGCCACCACCG CCACCGCCGCCCAGCTCCGGGAATGGACCAGCCCCTCCCCCACTCCCTCCTGCTCTGGTG CCTGCCGGGGGCCTGGCCCCTGGTGGGGGTCGGGGAGCGCTTTTGGATCAAATCCGGCAG GGAATTCAGCTGAACAAGACCCCTGGGGCCCCAGAGAGCTCAGCGCTGCAGCCACCACCT CAGAGCTCAGAGGGACTGGTGGGGGCCCTGATGCACGTGATGCAGAAGAGAAGCAGAGCC ATCCACTCCTCCGACGAAGGGGAGGACCAGGCTGGCGATGAAGATGAAGATGATGAATGG GATGACTGA
- Chromosome Location
- X
- Locus
- Xp11.23
- External Identifiers
Resource Link UniProtKB ID P42768 UniProtKB Entry Name WASP_HUMAN GenBank Gene ID U12707 GeneCard ID WAS GenAtlas ID WAS HGNC ID HGNC:12731 PDB ID(s) 1CEE, 1EJ5, 1T84, 2A3Z, 2K42, 2OT0 KEGG ID hsa:7454 NCBI Gene ID 7454 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (S)-wiskostatin experimental unknown target Details