U1 small nuclear ribonucleoprotein A
Details
- Name
- U1 small nuclear ribonucleoprotein A
- Kind
- protein
- Synonyms
- U1 snRNP A
- U1-A
- U1A
- Gene Name
- SNRPA
- UniProtKB Entry
- P09012Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0019322|U1 small nuclear ribonucleoprotein A MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFK EVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPA TKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQI PPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLV PGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
- Number of residues
- 282
- Molecular Weight
- 31279.365
- Theoretical pI
- 10.5
- GO Classification
- FunctionsDNA binding / identical protein binding / U1 snRNP bindingComponentsnucleus / U4/U6 x U5 tri-snRNP complex
- General Function
- Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs
- Specific Function
- Dna binding
- Pfam Domain Function
- RRM_1 (PF00076)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0019323|U1 small nuclear ribonucleoprotein A (SNRPA) ATGGCAGTTCCCGAGACCCGCCCTAACCACACTATTTATATCAACAACCTCAATGAGAAG ATCAAGAAGGATGAGCTAAAAAAGTCCCTGTACGCCATCTTCTCCCAGTTTGGCCAGATC CTGGATATCCTGGTATCACGGAGCCTGAAGATGAGGGGCCAGGCCTTTGTCATCTTCAAG GAGGTCAGCAGCGCCACCAACGCCCTGCGCTCCATGCAGGGTTTCCCTTTCTATGACAAA CCTATGCGTATCCAGTATGCCAAGACCGACTCAGATATCATTGCCAAGATGAAAGGCACC TTCGTGGAGCGGGACCGCAAGCGGGAGAAGAGGAAGCCCAAGAGCCAGGAGACCCCGGCC ACCAAGAAGGCTGTGCAAGGCGGGGGAGCCACCCCCGTGGTGGGGGCTGTCCAGGGGCCT GTCCCGGGCATGCCGCCGATGACTCAGGCGCCCCGCATTATGCACCACATGCCGGGCCAG CCGCCCTACATGCCGCCCCCTGGTATGATCCCCCCGCCAGGCCTTGCACCTGGCCAGATC CCACCAGGGGCCATGCCCCCGCAGCAGCTTATGCCAGGACAGATGCCCCCTGCCCAGCCT CTTTCTGAGAATCCACCGAATCACATCTTGTTCCTCACCAACCTGCCAGAGGAGACCAAC GAGCTCATGCTGTCCATGCTTTTCAATCAGTTCCCTGGCTTCAAGGAGGTCCGTCTGGTA CCCGGGCGGCATGACATCGCCTTCGTGGAGTTTGACAATGAGGTACAGGCAGGGGCAGCT CGCGATGCCCTGCAGGGCTTTAAGATCACGCAGAACAACGCCATGAAGATCTCCTTTGCC AAGAAGTAG
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID P09012 UniProtKB Entry Name SNRPA_HUMAN GenBank Gene ID M60784 GeneCard ID SNRPA GenAtlas ID SNRPA HGNC ID HGNC:11151 PDB ID(s) 1AUD, 1DRZ, 1DZ5, 1FHT, 1M5K, 1M5O, 1M5P, 1M5V, 1NU4, 1OIA, 1SJ3, 1SJ4, 1SJF, 1U6B, 1URN, 1VBX, 1VBY, 1VBZ, 1VC0, 1VC5, 1VC6, 1ZZN, 2A3J, 2NZ4, 2OIH, 2OJ3, 2U1A, 3BO2, 3BO3, 3BO4, 3CUL, 3CUN, 3EGZ, 3G8S, 3G8T, 3G96, 3G9C, 3HHN, 3IIN, 3IRW, 3IWN, 3K0J, 3L3C, 3MUM, 3MUR, 3MUT, 3MUV, 3MXH, 3P49, 3PGW, 3R1H, 3R1L, 3UCU, 3UCZ, 3UD3, 3UD4, 4C4W, 4PR6, 4PRF, 4W90, 4W92, 4YB1, 5DDO, 5DDP, 5DDQ, 5DDR, 5FJ4, 6LAS, 6LAU, 6LAX, 6LAZ, 6QX9, 6SQN, 6SQQ, 6SQT, 6SQV, 6SR7, 6XH0, 6XH1, 6XH2, 6XH3, 7AEP, 7B0Y, 7D7V, 7DLZ, 7DWH, 7LHX, 7QR3, 7QR4, 7VPX, 8GXB, 8GXC KEGG ID hsa:6626 NCBI Gene ID 6626 - General References
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- Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ: cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J. 1987 Dec 1;6(12):3841-8. [Article]
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- Nagai K, Oubridge C, Jessen TH, Li J, Evans PR: Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature. 1990 Dec 6;348(6301):515-20. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Malonic acid experimental unknown target Details