Nucleoside diphosphate kinase A

BE0003106ProteinHumansNME1

Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:10952986, PubMed:14960567, PubMed:16313181,... It is acted on by 23 drugs in DrugBank.

Gene name
NME1
UniProtKB entry
P15531Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
152 residues · 17,149 Da
Also known as
2.7.4.6 · Farnesyl diphosphate kinase NME1 · GAAD · Histidine protein kinase NME1 · Metastasis inhibition factor nm23

Resolves to

Protein
UniProtP15531UniProt nameNDKA_HUMAN
Gene
HGNCHGNC:7849NCBI Gene4830GeneCardsNME1
Pharmacology
KEGGhsa:4830
Structure
PDB1JXVPDB1UCNPDB2HVD
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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32GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nucleoside diphosphate kinase A, how selective are they, and which programs against it are still in active trials?

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