Gamma-secretase subunit APH-1A

BE0003409ProteinHumansAPH1A

Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12679784, PubMed:12763021, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). It is acted on by 12 drugs in DrugBank.

Gene name
APH1A
UniProtKB entry
Q96BI3Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
265 residues · 28,996 Da
Also known as
APH-1a · Aph-1alpha · Presenilin-stabilization factor · PSF

Resolves to

Protein
UniProtQ96BI3UniProt nameAPH1A_HUMAN
Gene
HGNCHGNC:29509NCBI Gene51107GeneCardsAPH1A
Pharmacology
KEGGhsa:51107
Structure
PDB5A63PDB5FN2PDB5FN3
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-secretase subunit APH-1A, how selective are they, and which programs against it are still in active trials?

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