Programmed cell death 1 ligand 1

BE0003441ProteinHumansCD274

Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). It is acted on by 30 drugs in DrugBank.

Gene name
CD274
UniProtKB entry
Q9NZQ7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
290 residues · 33,275 Da
Also known as
B7 homolog 1 · B7-H1 · B7H1 · hPD-L1 · PD-L1

Resolves to

Protein
UniProtQ9NZQ7UniProt namePD1L1_HUMAN
Gene
HGNCHGNC:17635NCBI Gene29126GeneCardsCD274
Pharmacology
KEGGhsa:29126
Structure
PDB3BIKPDB3BISPDB3FN3
Drugs

What you can answer from here — as of September 07, 2019

30DrugsApproved to experimental, with action, bond type and pharmacological action
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511Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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84+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Programmed cell death 1 ligand 1, how selective are they, and which programs against it are still in active trials?

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