Heat shock factor protein 1

BE0003514ProteinHumansHSF1

Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat... It is acted on by 3 drugs in DrugBank.

Gene name
HSF1
UniProtKB entry
Q00613Swiss-Prot
Cellular location
Nucleus
Residues / weight
529 residues · 57,260 Da
Also known as
Heat shock transcription factor 1 · HSF 1 · HSTF 1 · HSTF1

Resolves to

Protein
UniProtQ00613UniProt nameHSF1_HUMAN
Gene
HGNCHGNC:5224NCBI Gene3297GeneCardsHSF1
Pharmacology
KEGGhsa:3297
Structure
PDB2LDUPDB5D5UPDB5D5V
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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44GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Heat shock factor protein 1, and which indications are they being tested in?

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