Carbonic anhydrase 14
Details
- Name
- Carbonic anhydrase 14
- Kind
- protein
- Synonyms
- 4.2.1.1
- CA-XIV
- Carbonate dehydratase XIV
- Carbonic anhydrase XIV
- Gene Name
- CA14
- UniProtKB Entry
- Q9ULX7Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0012526|Carbonic anhydrase 14 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
- Number of residues
- 337
- Molecular Weight
- 37667.37
- Theoretical pI
- 6.34
- GO Classification
- Functionszinc ion bindingProcessesone-carbon metabolic processComponentsapical plasma membrane / basolateral plasma membrane / membrane
- General Function
- Reversible hydration of carbon dioxide
- Specific Function
- carbonate dehydratase activity
- Pfam Domain Function
- Carb_anhydrase (PF00194)
- Signal Regions
- 1-15
- Transmembrane Regions
- 291-311
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0012527|Carbonic anhydrase 14 (CA14) ATGTTGTTCTCCGCCCTCCTGCTGGAGGTGATTTGGATCCTGGCTGCAGATGGGGGTCAA CACTGGACGTATGAGGGCCCACATGGTCAGGACCATTGGCCAGCCTCTTACCCTGAGTGT GGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGAT TTGCCTGCTCTGCAGCCCCACGGATATGACCAGCCTGGCACCGAGCCTTTGGACCTGCAC AACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACTTCCC CGAAAATATGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGG TCAGAACACCAGATCAACAGTGAAGCCACATTTGCAGAGCTCCACATTGTACATTATGAC TCTGATTCCTATGACAGCTTGAGTGAGGCTGCTGAGAGGCCTCAGGGCCTGGCTGTCCTG GGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCAC TTGCATGAAGTCAGGCATAAAGATCAGAAGACCTCAGTGCCTCCCTTCAACCTAAGAGAG CTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCCCCCT TGCTACCAGAGTGTGCTCTGGACAGTTTTTTATAGAAGGTCCCAGATTTCAATGGAACAG CTGGAAAAGCTTCAGGGGACATTGTTCTCCACAGAAGAGGAGCCCTCTAAGCTTCTGGTA CAGAACTACCGAGCCCTTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCATCCAA GCAGGATCCTCGTATACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGC TGTCTCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTG GAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAGGCATAA
- Chromosome Location
- 1
- Locus
- 1q21.2
- External Identifiers
Resource Link UniProtKB ID Q9ULX7 UniProtKB Entry Name CAH14_HUMAN GenBank Protein ID 6009640 GenBank Gene ID AB025904 GeneCard ID CA14 HGNC ID HGNC:1372 PDB ID(s) 4LU3, 5CJF KEGG ID hsa:23632 IUPHAR/Guide To Pharmacology ID 2598 NCBI Gene ID 23632 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Acetazolamide approved, vet_approved yes target inhibitor Details Zonisamide approved, investigational unknown target inhibitor Details Ellagic acid investigational yes target inhibitor Details Ferulic acid experimental yes target inhibitor Details 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide experimental yes target inhibitor Details indane-5-sulfonamide experimental yes target inhibitor Details 4-(2-AMINOETHYL)BENZENESULFONAMIDE experimental yes target inhibitor Details Hexamethylene diamine experimental yes target inhibitor Details Cadaverine experimental yes target inhibitor Details p-Coumaric acid experimental yes target inhibitor Details p-Aminophenol experimental yes target inhibitor Details Resorcinol approved yes target inhibitor Details Coumarin experimental yes target inhibitor Details Cianidanol approved, withdrawn yes target inhibitor Details Curcumin approved, investigational yes target inhibitor Details Mafenide approved, vet_approved, withdrawn yes target inhibitor Details Triethylenetetramine approved, investigational yes target inhibitor Details Spermine experimental, nutraceutical yes target inhibitor Details Phenol approved, experimental yes target inhibitor Details