Solute carrier organic anion transporter family member 2A1

BE0003655ProteinHumansSLCO2A1

Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:11997326, PubMed:26692285, PubMed:8787677). It is acted on by 17 drugs in DrugBank.

Gene name
SLCO2A1
UniProtKB entry
Q92959Swiss-Prot
Cellular location
Cell membrane
Residues / weight
643 residues · 70,043 Da
Also known as
OATP2A1 · PGT · PHOAR2 · Prostaglandin transporter · SLC21A2

Resolves to

Protein
UniProtQ92959UniProt nameSO2A1_HUMAN
Gene
HGNCHGNC:10955NCBI Gene6578GenBank1617590GeneCardsSLCO2A1
Pharmacology
KEGGhsa:6578
Structure
PDB3MRRPDB8KGIPDB8KGV
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier organic anion transporter family member 2A1, how selective are they, and which programs against it are still in active trials?

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