The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as...
- Mechanism
- Curator reviewed
Dinoprost tromethamine appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions (via its interaction with the prostaglandin receptors) in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.
- Primary indication
- Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life.Curator reviewed
- Formula / weight
- C24H45NO8 · 475.616 g/mol (avg)
- First approval
- Canada, 2003
- Also known as
- Dinoprost trometamol · PGF2-alpha THAM · PGF2A THAM · PGF2alpha THAM · Prostin F2 Alpha
- Code names
- U-14,583E
Resolves to
IYGXEHDCSOYNKY-RZHHZEQLSA-NSMILESNC(CO)(CO)CO.CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=OWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Dinoprost tromethamine, and which of those have an active Phase 3 trial?
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