ATP-binding cassette sub-family C member 11

BE0003658ProteinHumansABCC11

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. It is acted on by 8 drugs in DrugBank.

Gene name
ABCC11
UniProtKB entry
Q96J66Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,382 residues · 154,300 Da
Also known as
7.6.2.2 · 7.6.2.3 · MRP8 · Multidrug resistance-associated protein 8

Resolves to

Protein
UniProtQ96J66UniProt nameMRP8_HUMAN
Gene
HGNCHGNC:14639NCBI Gene85320GenBank15027829GeneCardsABCC11
Pharmacology
KEGGhsa:85320
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 11, how selective are they, and which programs against it are still in active trials?

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