2-Hydroxyacid oxidase 1

BE0003766ProteinHumansHAO1

Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). It is acted on by 11 drugs in DrugBank.

Gene name
HAO1
UniProtKB entry
Q9UJM8Swiss-Prot
Cellular location
Peroxisome matrix
Residues / weight
370 residues · 40,924 Da
Also known as
1.1.3.15 · Glycolate oxidase · Glyoxylate oxidase · GO · GOX

Resolves to

Protein
UniProtQ9UJM8UniProt nameHAOX1_HUMAN
Gene
HGNCHGNC:4809NCBI Gene54363GenBank7530485GeneCardsHAO1
Pharmacology
KEGGhsa:54363
Structure
PDB2NZLPDB2RDTPDB2RDU
Drugs

What you can answer from here — as of September 03, 2024

11DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2-Hydroxyacid oxidase 1, how selective are they, and which programs against it are still in active trials?

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