Beta sliding clamp

BE0003771ProteinEscherichia coli (strain K12)dnaN

Confers DNA tethering and processivity to DNA polymerases and other proteins. It is acted on by 1 drug in DrugBank.

Gene name
dnaN
UniProtKB entry
P0A988Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
366 residues · 40,586 Da
Also known as
2.7.7.7 · Beta clamp · Beta-clamp processivity factor · DNA polymerase III beta sliding clamp subunit · DNA polymerase III subunit beta

Resolves to

Protein
UniProtP0A988UniProt nameDPO3B_ECOLI
Gene
NCBI Gene948218GenBank145759
Pharmacology
KEGGecj:JW3678
Structure
PDB1JQJPDB1JQLPDB1MMI
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Beta sliding clamp, and which indications are they being tested in?

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