Phenolphthalein

DB04824ApprovedWithdrawnSmall molecule

Phenolphthalein is a drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures. Phenolphthalein was withdrawn in Canada due to concerns with carcinogenicity in 1997.

Chemical structure of Phenolphthalein
Primary indication
Used for over a century as a laxative.Curator reviewed · 2 structured indications
Formula / weight
C20H14O4 · 318.3228 g/mol (avg)
First approval
Canada, 1971
Also known as
Phthalimetten · Phthalin · Yellow phenolphthalein

Resolves to

Compound
UNII6QK969R2IFCAS77-09-8ChEMBLCHEMBL63857ChEBI34914PubChem4764KEGGD05456
Clinical / RWD
RxNorm155122ATCA06AB04PharmGKBPA450915
Structure
InChIKeyKJFMBFZCATUALV-UHFFFAOYSA-NSMILESOC1=CC=C(C=C1)C1(OC(=O)C2=CC=CC=C12)C1=CC=C(O)C=C1
Targets
O60656UGT1A9O75469NR1I2Q14994NR1I3P03372ESR1P04278SHBG

What you can answer from here — as of January 17, 2025

5Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
394Drug interactionsStructured to mechanism, not free text
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2Structured indicationsCondition, population, route and combination as fields, not prose
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9ContraindicationsEach with its own population and attribute set
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53Marketed productsAcross 4 countries and 42 labellers
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1ATC codeIncluding every combination product, plus 10 drug categories
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5+ReferencesStructured and connected to the statements they support
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