Doxylamine is an antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy. Histamine H1 antagonist with pronounced sedative properties.
- Mechanism
- Curator reviewed
Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.
- Primary indication
- Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug.Curator reviewed · 6 structured indications
- Formula / weight
- C17H22N2O · 270.3694 g/mol (avg)
- First approval
- Canada, 1996 · United States, 1978
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
HCFDWZZGGLSKEP-UHFFFAOYSA-NSMILESCN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1Targets
What you can answer from here — as of September 21, 2026
3Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Doxylamine, and which of those have an active Phase 3 trial?
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