tRNA dimethylallyltransferase

BE0004051ProteinEscherichia coli (strain K12)miaA

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). It is acted on by 1 drug in DrugBank.

Gene name
miaA
UniProtKB entry
P16384Swiss-Prot
Residues / weight
316 residues · 35,065 Da
Also known as
2.5.1.75 · Dimethylallyl diphosphate:tRNA dimethylallyltransferase · DMAPP:tRNA dimethylallyltransferase · DMATase · IPP transferase

Resolves to

Protein
UniProtP16384UniProt nameMIAA_ECOLI
Gene
NCBI Gene948690
Pharmacology
KEGGecj:JW4129
Structure
PDB2ZM5PDB2ZXUPDB3FOZ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on tRNA dimethylallyltransferase, and which indications are they being tested in?

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