Tyrosine-protein kinase JAK1

BE0004145ProteinHumansJAK1

Non-membrane spanning protein tyrosine kinase that phosphorylates signal-transducing subunits of cytokine receptor complexes like IL2RB, IL10RA, IFNAR2, IL6ST, LIFR, OSMR and IL31RA (PubMed:11909529, PubMed:12133952, PubMed:15194700, PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552, PubMed:9188471). It is acted on by 31 drugs in DrugBank.

Gene name
JAK1
UniProtKB entry
P23458Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
1,154 residues · 133,276 Da
Also known as
2.7.10.2 · JAK-1 · JAK1A · JAK1B · Janus kinase 1

Resolves to

Protein
UniProtP23458UniProt nameJAK1_HUMAN
Gene
HGNCHGNC:6190NCBI Gene3716GeneCardsJAK1
Pharmacology
IUPHAR/GtoPdb2047KEGGhsa:3716
Structure
PDB3EYGPDB3EYHPDB4E4L
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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107+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase JAK1, how selective are they, and which programs against it are still in active trials?

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