Delgocitinib is a Janus kinase inhibitor used to treat hand eczema in adults. After the first global approval in Japan, delgocitinib was also approved by the European Commission on September 23, 2024.
- Mechanism
- Curator reviewed · 6 references
Delgocitinib is a pan Janus kinase (JAK) inhibitor that targets the activity of all four members of the JAK family [JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2)] in a concentration-dependent manner. JAK family has been implicated in several inflammatory disorders, as they mediate the signalling of inflammatory cytokines. In human cells, inhibition of the JAK-STAT pathway by delgocitinib attenuates the signalling of several pro-inflammatory cytokines (including interleukin (IL)-2, IL-4, IL-6, IL-13, IL-21, IL-23, Granulocyte-Macrophage-Colony-Stimulating Factor (GM-CSF), and Interferon (IFN)-α) downregulating the immune and inflammatory responses in cells of relevance to CHE pathology. Delgocitinib blocks the activation of inflammatory cells, such as T cells, B cells, monocytes and mast cells, and the production of cytokines.
- Primary indication
- Delgocitinib is indicated for the treatment of moderate to severe chronic hand eczema (CHE) in adults for whom topical corticosteroids are inadequate or inappropriate.Curator reviewed · 4 structured indications
- Formula / weight
- C16H18N6O · 310.361 g/mol (avg)
- First approval
- Canada, 2025 · United States, 2025 · European Union, 2025
- Also known as
- 1,6-DIAZASPIRO(3.4)OCTANE-1-PROPANENITRILE, 3-METHYL-.BETA.-OXO-6-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)-, (3S,4R)- · 3-[(3S,4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
- Code names
- JTE-052 · JTE-052A · LEO-124249 · LEO-124249A
Resolves to
LOWWYYZBZNSPDT-ZBEGNZNMSA-NSMILESC[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)C1=C2C=CNC2=NC=N1What you can answer from here — as of September 16, 2026
Which drugs share a target with Delgocitinib, and which of those have an active Phase 3 trial?
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