Non-receptor tyrosine-protein kinase TYK2

BE0004146ProteinHumansTYK2

Non-membrane spanning protein tyrosine kinase involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). It is acted on by 18 drugs in DrugBank.

Gene name
TYK2
UniProtKB entry
P29597Swiss-Prot
Residues / weight
1,187 residues · 133,649 Da
Also known as
2.7.10.2

Resolves to

Protein
UniProtP29597UniProt nameTYK2_HUMAN
Gene
HGNCHGNC:12440NCBI Gene7297GenBank37504GeneCardsTYK2
Pharmacology
IUPHAR/GtoPdb2269KEGGhsa:7297
Structure
PDB3LXNPDB3LXPPDB3NYX
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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58+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Non-receptor tyrosine-protein kinase TYK2, how selective are they, and which programs against it are still in active trials?

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