6-pyruvoyl tetrahydrobiopterin synthase

BE0004520ProteinHumansPTS

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. It is acted on by 2 drugs in DrugBank.

Gene name
PTS
UniProtKB entry
Q03393Swiss-Prot
Residues / weight
145 residues · 16,386 Da
Also known as
4.2.3.12 · PTP synthase · PTPS

Resolves to

Protein
UniProtQ03393UniProt namePTPS_HUMAN
Gene
HGNCHGNC:9689NCBI Gene5805GeneCardsPTS
Pharmacology
KEGGhsa:5805
Structure
PDB3I2B
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 6-pyruvoyl tetrahydrobiopterin synthase, how selective are they, and which programs against it are still in active trials?

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