Transient receptor potential cation channel subfamily M member 7

BE0004624ProteinHumansTRPM7

Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. It is acted on by 8 drugs in DrugBank.

Gene name
TRPM7
UniProtKB entry
Q96QT4Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,865 residues · 212,695 Da
Also known as
2.7.11.1 · CHAK1 · Channel-kinase 1 · Long transient receptor potential channel 7 · LTrpC-7

Resolves to

Protein
UniProtQ96QT4UniProt nameTRPM7_HUMAN
Gene
HGNCHGNC:17994NCBI Gene54822GeneCardsTRPM7
Pharmacology
IUPHAR/GtoPdb499KEGGhsa:54822
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transient receptor potential cation channel subfamily M member 7, how selective are they, and which programs against it are still in active trials?

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