A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in...
- Mechanism
- Curator reviewed
Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known.
- Primary indication
- Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated).Curator reviewed
- Formula / weight
- C18H22O4 · 302.3649 g/mol (avg)
- Also known as
- erythro-nordihydroguaiaretic acid · meso-NDGA · meso-nordihydroguaiaretic acid · Nordihydroguaiaretic acid
- Code names
- CHX-100 · INSM-18 · NSC-4291
Resolves to
HCZKYJDFEPMADG-TXEJJXNPSA-NSMILESC[C@@H](CC1=CC(O)=C(O)C=C1)[C@H](C)CC1=CC(O)=C(O)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Masoprocol, and which of those have an active Phase 3 trial?
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