Sodium-coupled monocarboxylate transporter 1

BE0004708ProteinHumansSLC5A8

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate)... It is acted on by 7 drugs in DrugBank.

Gene name
SLC5A8
UniProtKB entry
Q8N695Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
610 residues · 66,577 Da
Also known as
AIT · Apical iodide transporter · Electrogenic sodium monocarboxylate cotransporter · SMCT · SMCT1

Resolves to

Protein
UniProtQ8N695UniProt nameSC5A8_HUMAN
Gene
HGNCHGNC:19119NCBI Gene160728GeneCardsSLC5A8
Pharmacology
IUPHAR/GtoPdb922KEGGhsa:160728
Structure
PDB7SL9
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium-coupled monocarboxylate transporter 1, how selective are they, and which programs against it are still in active trials?

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