Tyrosine-protein kinase Fgr

BE0005539ProteinHumansFGR

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to... It is acted on by 4 drugs in DrugBank.

Gene name
FGR
UniProtKB entry
P09769Swiss-Prot
Cellular location
Cell membrane
Residues / weight
529 residues · 59,478 Da
Also known as
2.7.10.2 · Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog · p55-Fgr · p58-Fgr · p58c-Fgr

Resolves to

Protein
UniProtP09769UniProt nameFGR_HUMAN
Gene
HGNCHGNC:3697NCBI Gene2268GeneCardsFGR
Pharmacology
IUPHAR/GtoPdb2024KEGGhsa:2268
Structure
PDB7JT9PDB7UY0PDB7UY3
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Fgr, how selective are they, and which programs against it are still in active trials?

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