HLA class I histocompatibility antigen, B-27 alpha chain
Details
- Name
- HLA class I histocompatibility antigen, B-27 alpha chain
- Kind
- protein
- Synonyms
- HLAB
- MHC class I antigen B*27
- Gene Name
- HLA-B
- UniProtKB Entry
- P01889Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0012842|HLA class I histocompatibility antigen, B-27 alpha chain MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRF DSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQ NMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQL RAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP SSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSL TA
- Number of residues
- 362
- Molecular Weight
- 40427.835
- Theoretical pI
- 5.63
- GO Classification
- Functionspeptide antigen bindingProcessesantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of peptide antigen via MHC class I / cytokine-mediated signaling pathway / defense response / detection of bacterium / immune response / interferon-gamma-mediated signaling pathway / regulation of immune response / type I interferon signaling pathway / viral processComponentscell surface / early endosome membrane / endoplasmic reticulum / ER to Golgi transport vesicle membrane / extracellular exosome / Golgi apparatus / Golgi membrane / integral component of lumenal side of endoplasmic reticulum membrane / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane
- General Function
- Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).
- Specific Function
- peptide antigen binding
- Pfam Domain Function
- Signal Regions
- 1-24
- Transmembrane Regions
- 309-332
- Cellular Location
- Membrane
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- 6p21.3
- External Identifiers
Resource Link UniProtKB ID P01889 UniProtKB Entry Name 1B27_HUMAN GenBank Protein ID 896271 GenBank Gene ID L38504 HGNC ID HGNC:4932 PDB ID(s) 1HSA, 1JGD, 1JGE, 1K5N, 1OF2, 1OGT, 1ROG, 1ROH, 1ROI, 1ROJ, 1ROK, 1ROL, 1UXS, 1UXW, 1W0V, 1W0W, 2A83, 2BSR, 2BSS, 2BST, 3B3I, 3B6S, 3BP4, 3BP7, 3CZF, 3D18, 3DTX, 3HCV, 3LV3, 4G8G, 4G8I, 4G9D, 4G9F - General References
- Weiss EH, Kuon W, Dorner C, Lang M, Riethmuller G: Organization, sequence and expression of the HLA-B27 gene: a molecular approach to analyze HLA and disease associations. Immunobiology. 1985 Dec;170(5):367-80. [Article]
- Szots H, Riethmuller G, Weiss E, Meo T: Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1428-32. [Article]
- Ezquerra A, Bragado R, Vega MA, Strominger JL, Woody J, Lopez de Castro JA: Primary structure of papain-solubilized human histocompatibility antigen HLA-B27. Biochemistry. 1985 Mar 26;24(7):1733-41. [Article]
- Seemann GH, Rein RS, Brown CS, Ploegh HL: Gene conversion-like mechanisms may generate polymorphism in human class I genes. EMBO J. 1986 Mar;5(3):547-52. [Article]
- Moses JH, Marsh SG, Arnett KL, Adams EJ, Bodmer JG, Parham P: On the nucleotide sequences of B*2702 and B*2705. Tissue Antigens. 1995 Jul;46(1):50-3. [Article]
- Vega MA, Ezquerra A, Rojo S, Aparicio P, Bragado R, Lopez de Castro JA: Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7394-8. [Article]
- Choo SY, St John T, Orr HT, Hansen JA: Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) identifies a unique single amino acid substitution. Hum Immunol. 1988 Mar;21(3):209-19. [Article]
- Rudwaleit M, Bowness P, Wordsworth P: The nucleotide sequence of HLA-B*2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B*2706. Immunogenetics. 1996;43(3):160-2. [Article]
- Coppin HL, McDevitt HO: Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients. J Immunol. 1986 Oct 1;137(7):2168-72. [Article]
- Vilches C, de Pablo R, Kreisler M: Nucleotide sequence of HLA-B*2706. Immunogenetics. 1994;39(3):219. [Article]
- Choo SY, Fan LA, Hansen JA: A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain. J Immunol. 1991 Jul 1;147(1):174-80. [Article]
- Hildebrand WH, Domena JD, Shen SY, Marsh SG, Bunce M, Guttridge MG, Darke C, Parham P: The HLA-B7Qui antigen is encoded by a new subtype of HLA-B27 (B*2708). Tissue Antigens. 1994 Jul;44(1):47-51. [Article]
- Del Porto P, D'Amato M, Fiorillo MT, Tuosto L, Piccolella E, Sorrentino R: Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone. J Immunol. 1994 Oct 1;153(7):3093-100. [Article]
- Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
- Madden DR, Gorga JC, Strominger JL, Wiley DC: The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell. 1992 Sep 18;70(6):1035-48. [Article]
- Madden DR, Gorga JC, Strominger JL, Wiley DC: The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature. 1991 Sep 26;353(6342):321-5. [Article]
- Hulsmeyer M, Hillig RC, Volz A, Ruhl M, Schroder W, Saenger W, Ziegler A, Uchanska-Ziegler B: HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J Biol Chem. 2002 Dec 6;277(49):47844-53. Epub 2002 Sep 18. [Article]
- Rognan D, Scapozza L, Folkers G, Daser A: Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):753-7. [Article]
- Varnavidou-Nicolaidou A, Karpasitou K, Georgiou D, Stylianou G, Kokkofitou A, Michalis C, Constantina C, Gregoriadou C, Kyriakides G: HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707. Hum Immunol. 2004 Dec;65(12):1451-4. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-Formylmethionine experimental unknown target Details Coccidioides immitis spherule approved unknown target Details