HLA class I histocompatibility antigen, B-27 alpha chain

Details

Name
HLA class I histocompatibility antigen, B-27 alpha chain
Kind
protein
Synonyms
  • HLAB
  • MHC class I antigen B*27
Gene Name
HLA-B
UniProtKB Entry
P01889Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0012842|HLA class I histocompatibility antigen, B-27 alpha chain
MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRF
DSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQ
NMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQL
RAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP
SSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSL
TA
Number of residues
362
Molecular Weight
40427.835
Theoretical pI
5.63
GO Classification
Functions
peptide antigen binding
Processes
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of peptide antigen via MHC class I / cytokine-mediated signaling pathway / defense response / detection of bacterium / immune response / interferon-gamma-mediated signaling pathway / regulation of immune response / type I interferon signaling pathway / viral process
Components
cell surface / early endosome membrane / endoplasmic reticulum / ER to Golgi transport vesicle membrane / extracellular exosome / Golgi apparatus / Golgi membrane / integral component of lumenal side of endoplasmic reticulum membrane / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane
General Function
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).
Specific Function
peptide antigen binding
Pfam Domain Function
Signal Regions
1-24
Transmembrane Regions
309-332
Cellular Location
Membrane
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
6p21.3
External Identifiers
ResourceLink
UniProtKB IDP01889
UniProtKB Entry Name1B27_HUMAN
GenBank Protein ID896271
GenBank Gene IDL38504
HGNC IDHGNC:4932
PDB ID(s)1HSA, 1JGD, 1JGE, 1K5N, 1OF2, 1OGT, 1ROG, 1ROH, 1ROI, 1ROJ, 1ROK, 1ROL, 1UXS, 1UXW, 1W0V, 1W0W, 2A83, 2BSR, 2BSS, 2BST, 3B3I, 3B6S, 3BP4, 3BP7, 3CZF, 3D18, 3DTX, 3HCV, 3LV3, 4G8G, 4G8I, 4G9D, 4G9F
General References
  1. Weiss EH, Kuon W, Dorner C, Lang M, Riethmuller G: Organization, sequence and expression of the HLA-B27 gene: a molecular approach to analyze HLA and disease associations. Immunobiology. 1985 Dec;170(5):367-80. [Article]
  2. Szots H, Riethmuller G, Weiss E, Meo T: Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1428-32. [Article]
  3. Ezquerra A, Bragado R, Vega MA, Strominger JL, Woody J, Lopez de Castro JA: Primary structure of papain-solubilized human histocompatibility antigen HLA-B27. Biochemistry. 1985 Mar 26;24(7):1733-41. [Article]
  4. Seemann GH, Rein RS, Brown CS, Ploegh HL: Gene conversion-like mechanisms may generate polymorphism in human class I genes. EMBO J. 1986 Mar;5(3):547-52. [Article]
  5. Moses JH, Marsh SG, Arnett KL, Adams EJ, Bodmer JG, Parham P: On the nucleotide sequences of B*2702 and B*2705. Tissue Antigens. 1995 Jul;46(1):50-3. [Article]
  6. Vega MA, Ezquerra A, Rojo S, Aparicio P, Bragado R, Lopez de Castro JA: Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7394-8. [Article]
  7. Choo SY, St John T, Orr HT, Hansen JA: Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) identifies a unique single amino acid substitution. Hum Immunol. 1988 Mar;21(3):209-19. [Article]
  8. Rudwaleit M, Bowness P, Wordsworth P: The nucleotide sequence of HLA-B*2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B*2706. Immunogenetics. 1996;43(3):160-2. [Article]
  9. Coppin HL, McDevitt HO: Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients. J Immunol. 1986 Oct 1;137(7):2168-72. [Article]
  10. Vilches C, de Pablo R, Kreisler M: Nucleotide sequence of HLA-B*2706. Immunogenetics. 1994;39(3):219. [Article]
  11. Choo SY, Fan LA, Hansen JA: A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain. J Immunol. 1991 Jul 1;147(1):174-80. [Article]
  12. Hildebrand WH, Domena JD, Shen SY, Marsh SG, Bunce M, Guttridge MG, Darke C, Parham P: The HLA-B7Qui antigen is encoded by a new subtype of HLA-B27 (B*2708). Tissue Antigens. 1994 Jul;44(1):47-51. [Article]
  13. Del Porto P, D'Amato M, Fiorillo MT, Tuosto L, Piccolella E, Sorrentino R: Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone. J Immunol. 1994 Oct 1;153(7):3093-100. [Article]
  14. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  15. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  16. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  17. Madden DR, Gorga JC, Strominger JL, Wiley DC: The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell. 1992 Sep 18;70(6):1035-48. [Article]
  18. Madden DR, Gorga JC, Strominger JL, Wiley DC: The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature. 1991 Sep 26;353(6342):321-5. [Article]
  19. Hulsmeyer M, Hillig RC, Volz A, Ruhl M, Schroder W, Saenger W, Ziegler A, Uchanska-Ziegler B: HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J Biol Chem. 2002 Dec 6;277(49):47844-53. Epub 2002 Sep 18. [Article]
  20. Rognan D, Scapozza L, Folkers G, Daser A: Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):753-7. [Article]
  21. Varnavidou-Nicolaidou A, Karpasitou K, Georgiou D, Stylianou G, Kokkofitou A, Michalis C, Constantina C, Gregoriadou C, Kyriakides G: HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707. Hum Immunol. 2004 Dec;65(12):1451-4. [Article]
  22. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N-FormylmethionineexperimentalunknowntargetDetails
Coccidioides immitis spheruleapprovedunknowntargetDetails