Histone deacetylase 5

BE0009578ProteinHumansHDAC5

In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). It is acted on by 1 drug in DrugBank.

Gene name
HDAC5
UniProtKB entry
Q9UQL6Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,122 residues · 121,977 Da
Also known as
3.5.1.98 · Antigen NY-CO-9 · HD5 · KIAA0600

Resolves to

Protein
UniProtQ9UQL6UniProt nameHDAC5_HUMAN
Gene
HGNCHGNC:14068NCBI Gene10014GeneCardsHDAC5
Pharmacology
IUPHAR/GtoPdb2660KEGGhsa:10014
Structure
PDB5UWIPDB8Q9P
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Histone deacetylase 5, and which indications are they being tested in?

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