Nuclear factor erythroid 2-related factor 2

BE0010121ProteinHumansNFE2L2

Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and... It is acted on by 20 drugs in DrugBank.

Gene name
NFE2L2
UniProtKB entry
Q16236Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
605 residues · 67,826 Da
Also known as
NF-E2-related factor 2 · NFE2-related factor 2 · Nrf-2 · NRF2 · Nuclear factor, erythroid derived 2, like 2

Resolves to

Protein
UniProtQ16236UniProt nameNF2L2_HUMAN
Gene
HGNCHGNC:7782NCBI Gene4780GeneCardsNFE2L2
Pharmacology
KEGGhsa:4780
Structure
PDB2FLUPDB2LZ1PDB3ZGC
Drugs

What you can answer from here — as of November 09, 2021

20DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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57+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear factor erythroid 2-related factor 2, how selective are they, and which programs against it are still in active trials?

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