Biological Factors
- Name
- Biological Factors
- Accession Number
- DBCAT000036
- Description
Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.
- Drugs
Drug Drug Description Urokinase A low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines. Reteplase A purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. Pegfilgrastim A recombinant human granulocyte colony stimulating factor used to stimulate the production of neutrophils and prevent febrile neutropenia or infections after myelosuppressive chemotherapy. Anakinra A recombinant form of human interleukin-1 receptor antagonist used in the treatment of rheumatoid arthritis, neonatal-onset multisystem inflammatory disease and deficiency of interleukin-1 receptor antagonist (DIRA). Coagulation factor VIIa Recombinant Human A form of recombinant human coagulation Factor VII used to treat hemophilia A and B. Botulinum toxin type A A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications. Filgrastim A form of recombinant human granulocyte colony stimulating factor used to induce the production of granulocytes and lower infection risk after myelosuppressive therapy. Enfuvirtide An HIV-1 gp41 fusion inhibitor used in patients experiencing HIV-1 replication who are already being treated with other anti-retrovirals. Folic acid A nutrient used to treat megaloblastic anemia and is found in many supplements. Vitamin A A vitamin important for retinal function that is used clinically to correct vitamin A deficiency. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Latanoprost An isopropyl ester prodrug used to treat increased intraocular pressure. Bimatoprost A prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. Misoprostol A prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers. Isotretinoin A retinoid used to treat severe recalcitrant acne. Exenatide A GLP-1 agonist used in the management of type 2 diabetes mellitus. Mecasermin A recombinant insulin-like growth factor-1 used for the long-term treatment of growth failure in pediatric patients with primary IGF-1 deficiency or with growth hormone gene deletion due to the development of neutralizing antibodies to GH. Adecatumumab Investigated for use/treatment in breast cancer and prostate cancer. Keyhole limpet hemocyanin Investigated for use/treatment in bladder cancer and solid tumors. PRO-542 Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, HIV infection, and pediatric indications. Unoprostone A prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents. Tafluprost An ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metreleptin A leptin analogue used as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. Methoxy polyethylene glycol-epoetin beta A synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease. Peginterferon beta-1a An interferon beta used to treat relapsing forms of multiple sclerosis. Omega-3-acid ethyl esters A mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia. Protein C A medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis. Bambermycins Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... Antithrombin III human An alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency. Tuberculin purified protein derivative A purified protein used in the Mantoux test for Mycobacterium tuberculosis testing. Antihemophilic factor human A Factor VIII replacement therapy used to treat hemophilia A. Meningococcal polysaccharide vaccine group A Meningococcal group A polysaccharide is group-specific polysaccharide antigens extracted and purified from Neisseria meningitidis serogroup A. N. meningitidis is a bacteria that causes endemic and epidemic diseases including meningitis and... p-Phenylenediamine Not Annotated Hepatitis B Vaccine (Recombinant) A solution of Hepatitis B surface antigen used to immunize patients against Hepatitis B. Turoctocog alfa pegol Turoctocog alfa pegol is indicated for use in adults and children with hemophilia A for on-demand treatment and control of bleeding episodes, perioperative management of bleeding, and routine prophylaxis to... Human interferon beta A polypeptide drug used in the treatment of relapsing forms of Multiple Sclerosis (MS). Bevifimod Bevifimod is under investigation in clinical trial NCT01749787 (Safety Study of PRTX-100 With Methotrexate or Leflunomide to Treat Active Rheumatoid Arthritis). Thrombin alfa A platelet activating factor used to treat minor bleeding. Axicabtagene ciloleucel A CAR T-cell therapy used to treat adults with large B-cell lymphomas and follicular lymphoma. O-(N-acetyl-alpha-D-galactosaminyl)-L-serine Not Available Human blood group H type 1 trisaccharide Not Available Eftilagimod alfa Eftilagimod alfa is under investigation in clinical trial NCT02614833 (IMP321 (Eftilagimod Alpha) as Adjunctive to a Standard Chemotherapy Paclitaxel Metastatic Breast Carcinoma). Fosdenopterin An exogenous form of cyclic pyranopterin monophosphate (cPMP) used as a replacement substrate in patients with molybdenum cofactor deficiency (MoCD) type A. Zinc glycinate Glycoprotein marker of gastrointestinal cancer. Ceramide NP Ceramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3... Squaric acid dibutyl ester Squaric acid dibutyl ester is under investigation in clinical trial NCT01971385 (Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis). Blatella germanica An extract from Blatella germanica used in allergy testing. Rhizopus arrhizus var. arrhizus An extract from Rhizopus arrhizus var. arrhizus used in allergy testing. Ustilago nuda hordei An extract from Ustilago nuda hordei used in allergy testing. Ditiocarb zinc Ditiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... Ethylenediamine Ethylenediamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Bromothalonil Bromothalonil is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Disperse Blue 106 Disperse Blue 106 is used in allergenic testing. Dermatophagoides farinae An extract from Dermatophagoides farinae used in allergy testing. Dermatophagoides pteronyssinus An extract from Dermatophagoides pteronyssinus used in allergy testing. Iodopropynyl butylcarbamate Not Annotated Becaplermin A recombinant form of human platelet-derived growth factor used to treat ulcers due to diabetic neuropathy in the lower extremities when there is adequate blood supply to the area. Alprostadil A medication used to treat erectile dysfunction. Lucinactant Intended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS. Ancrod An anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country. Cobiprostone Investigated for use/treatment in cystic fibrosis. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Gemeprost A prostaglandin E1 analogue used for cervical dilation and, in combination with mifepristone, for pregnancy termination. Limaprost An oral prostaglandin E1 analogue used to improve symptoms associated with thromboangiitis obliterans, acquired lumbar spinal canal stenosis, and other ischemic conditions. Angiotensin 1-7 TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities. Cenderitide Cenderitide is under investigation for the treatment of ST Elevation (STEMI) Myocardial Infarction of Anterior Wall. Angiotensin II A peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock. Cilengitide Cilengitide has been used in trials studying the treatment of Sarcoma, Gliomas, Lymphoma, Leukemia, and Lung Cancer, among others. Aclerastide Aclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic. Aviscumine Cy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy). Angiotensinamide Not Annotated Anfibatide Anfibatide is under investigation in clinical trial NCT01585259 (Anfibatide Phase Ib-IIa Clinical Trial). Denileukin diftitox A recombinant cytotoxic protein based on a combination of diphtheria toxin fragments and interleukin-2 used to treat cutaneous T-cell lymphoma by targeting the interleukin-2 receptor. Peginterferon alfa-2a A modified form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses. Interferon alfa-n1 A purified form of human interferon used to stimulate the innate antiviral response in the treatment of genital warts due to human papilloma virus. Erythropoietin A recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia. Interferon alfa-n3 A purified form of human interferon used to stimulate the innate antiviral response in the treatment of genital warts due to human papilloma virus. Sargramostim A modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant. Peginterferon alfa-2b A purified form of human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C, genital warts, and some cancers. Antihemophilic factor, human recombinant A form of recombinant coagulation Factor VIII used to treat hemophilia A, von Willebrand disease, and Factor XIII deficiency. Tenecteplase A modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli. Interferon gamma-1b A form of recombinant human interferon used to treat infections associated with chronic granulomatous disease and to slow the progression of severe malignant osteopetrosis. Interferon alfa-2a A form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses. Oprelvekin A form of recombinant interleukin-11 used to stimulate production of megakaryocytes and platelets in patients with or at risk of thrombocytopenia after chemotherapy. Palifermin A form of recombinant human keratinocyte growth factor used to prevent and treat oral mucositis following radiation or chemotherapy. Aldesleukin A recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma. Botulinum toxin type B A purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea. Drotrecogin alfa A form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII. Interferon beta-1a A form of recombinant human interferon used to slow disease progression and reduce the frequency of clinical symptoms in patients who have relapsing multiple sclerosis. Interferon beta-1b A form of recombinant human interferon used to slow the progression of relapsing multiple sclerosis and to reduce the frequency of clinical symptoms. Interferon alfacon-1 A recombinant interferon similar the interferon alfa subtype which is used to treat hepatitis C infections. Interferon alfa-2b A form of recombinant human interferon used to treat hepatitis B and C infection, genital warts, hairy cell leukemia, follicular lymphoma, malignant melanoma, and AIDs-related Kaposi's sarcoma. Ascorbic acid A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron. Lutein Xanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance. Riboflavin A vitamin used to correct vitamin B2 deficiency. Vitamin E An antioxidant vitamin used in many skin creams and multivitamin preparations. Lipoic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Masoprocol Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Treprostinil A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. Pramipexole A non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). Carboprost tromethamine A prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective. Acitretin An oral retinoid used in the treatment of severe psoriasis. Alitretinoin A vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. Porfimer sodium A hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus. Tretinoin A vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles. Dinoprostone A prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. Etretinate For the treatment of severe psoriasis in adults. Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Iloprost A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Dinoprost tromethamine Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities... Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Calcium A mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Probucol Used to lower LDL and HDL cholesterol. Kojic acid Not Available 3,4-Dihydroxycinnamic Acid Not Available N-Methylmesoporphyrin N-methylmesoporphyrin is a solid. This compound belongs to the porphyrins. These are compounds containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to... Prostaglandin D2 The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important... 6-Hydroxymethyl-7,8-Dihydropterin Not Available Platelet Activating Factor Not Available Protoporphyrin Not Available Prostaglandin B2 Not Available Cyclo(his-pro) Not Available Hydrogenobyrinic acid Not Available Mesoheme The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins. 6-hydroxy-FAD Not Available 4-Oxoretinol Not Available Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Siroheme Not Available Calyculin A Not Available Arotinoid acid Arotinoid acid is a retinoic acid analog which acts as a selective RAR agonist. Anhydrovitamin A Not Available Peridinin Not Available Flavin adenine dinucleotide A coenzyme form of vitamin B2 used in clinical conditions associated with vitamin B2 deficiency. 6-Hydroxymethylpterin Not Available Flavin mononucleotide A form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia. Ferroheme C Not Available Hemin An iron-containing porphyrin injection used for the relief of recurrent attacks of acute intermittent porphyria (AIP) associated with the menstrual cycle when carbohydrate therapy is not effective. Diacetyldeuteroheme Not Available Violaxanthin Not Available Heme D Not Available Coproporphyrin I Not Available Dihydrolipoic Acid Not Available Prostaglandin G2 A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem] Coenzyme F420 Not Available N-Ethylretinamide N-Ethylretinamide is the ethylamide of all-trans B-retinoic acid. Zinc protoporphyrin Not Available p-Coumaric acid Not Available Pteroic acid Not Available Quercetin A natural flavonoid found in foods and natural supplement products. N-acetylserotonin Not Available Lumichrome Not Available N-acetylhistamine Not Available 2,5-di-tert-butylhydroquinone Not Available Lumiflavin Not Available Verdoheme Not Available Stannsoporfin Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications. Eritoran Investigated for use/treatment in sepsis and septicemia. Lemuteporfin Intended for the treatment of benign prostatic hyperplasia and prostrate disorders. Fenretinide Investigated for use/treatment in macular degeneration. Abaloparatide A parathyroid hormone-related protein (PTHrP) analog used for the treatment of osteoporosis in patients with a high risk of fracture. Leptin Investigated for use/treatment in lipodystrophy and obesity. Topsalysin Investigated for use/treatment in benign prostatic hyperplasia, cancer/tumors (unspecified), prostate cancer, prostate disorders, and solid tumors. Beraprost For the treatment of pulmonary hypertension. Tetrodotoxin For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence. Interferon alfa An immunomodulator used to treat hepatitis B and C as well as certain types of cancer including cutaneous T-cell lymphoma and renal cell carcinoma. Motexafin lutetium Investigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease. Cintredekin besudotox Investigated for use/treatment in brain cancer. Romiplostim A fusion protein thrombopoietin (TPO) peptide analog that increases platelet counts by binding to and activating the human TPO receptor. Used to treat thrombocytopenia associated with chronic immune thrombocytopenia (ITP). Ciliary neurotrophic factor Investigated for use/treatment in eye disorders/infections, macular degeneration, and retinal disorders (unspecified). Histamine An ingredient of topical drugs for the relief of joint pain or muscle aches and pains. Regramostim Investigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant. Albinterferon Alfa-2B Investigated for use/treatment in hepatitis (viral, C). Tifuvirtide Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection. Motexafin gadolinium Investigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's). Chlorotoxin I-131 Investigated for use/treatment in various forms of brain cancer; Malignant Glioma, Glioblastoma Multiforme, GBM, Anaplastic Astrocytoma, Oligo-Astrocytoma, Gliosarcoma Praconase Investigated for use/treatment in spinal cord injuries. Fibroblast growth factor-1 Investigated for use/treatment in coronary artery disease and peripheral vascular disease. IRX-2 Investigated for use/treatment in cancer/tumors (unspecified), head and neck cancer, and solid tumors. IRX-5183 Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified). Maxy-G34 Investigated for use/treatment in adverse effects (chemotherapy) and neutropenics. alpha-Conotoxin VC 1.1 Investigated for use/treatment in pain (acute or chronic). LGD-1550 Investigated for use/treatment in cancer/tumors (unspecified). AEOL-10150 Investigated for use/treatment in amyotrophic lateral sclerosis (ALS). Sar9, Met (O2)11-Substance P Investigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection. CTCE-0214 Investigated for use/treatment in adverse effects (chemotherapy), blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), neutropenics, and vascular diseases. GI-5005 Investigated for use/treatment in hepatitis (viral, C). IRL-1620 Investigated for use/treatment in cancer/tumors (unspecified). Talotrexin Investigated for use/treatment in solid tumors, lung cancer, leukemia (unspecified), and leukemia (lymphoid). Icatibant A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE). Nelipepimut-S Investigated for use/treatment in prostate cancer and breast cancer. Trafermin Investigated for use/treatment in coronary artery disease, peripheral vascular disease, periodontal disease, bone fractures, entero-related fistulae, and diabetic foot ulcers. Lanoteplase Investigated for use/treatment in myocardial infarction. Nicaraven Investigated for use/treatment in cerebrovascular disease (unspecified). Endostatin Investigated for use/treatment in cancer/tumors (unspecified), macular degeneration, and diabetic retinopathy. Repifermin Investigated for use/treatment in bone marrow transplant, ulcers, and inflammatory bowel disease. E5531 Investigated for use/treatment in sepsis and septicemia. Velafermin Investigated for use/treatment in adverse effects (chemotherapy). Thrombopoietin Investigated for use/treatment in thrombocytopenia. Astaxanthin Investigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma. Labradimil Investigated for use/treatment in brain cancer and pediatric indications. Emfilermin Investigated for use/treatment in adverse effects (chemotherapy), reproductive health, and infertility. Rostaporfin Investigated for use/treatment in macular degeneration. Amediplase Investigated for use/treatment in myocardial infarction and thrombosis. Beta carotene A vitamin A precursor found in various nutritional supplements and health products. Saralasin Not Annotated 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid Not Available t-Butylhydroquinone Not Available Hypothemycin Not Available Tricetin Not Available Ro 12-7310 Not Available Uric acid At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke. Leukotriene C4 The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates... Batroxobin No approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously. Carbazochrome Indicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura. Idebenone An analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON). Ancestim A human stem cell factor used in combination with filgrastim during autologous peripheral blood progenitor cell (PBPC) transplantation to increase PBPC mobilization for improved collection. Turoctocog alfa An antihemorrhagic agent used for the treatment and prophylaxis of bleeding in patients of all ages with haemophilia A (congenital factor VIII deficiency). Chromic chloride A supplement to intravenous solutions given for total parenteral nutrition (TPN). Fibrinogen human A hemostatic agent used for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia. Silibinin A flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis. Antihemophilic factor (recombinant), PEGylated For the management of hemophilia A (congenital factor VIII deficiency) [FDA label], . This medication is a human antihemophilic factor indicated in adolescent and adult patients (12 years and older)... Thiosulfuric acid A sulfur donor used sequentially with sodium nitrite for the reversal of life-threatening acute cyanide poisoning. Also used to reduce the risk of ototoxicity associated with cisplatin. Mequinol A topical agent used in combination with tretinoin to treat solar lentigines. Hydroquinone A topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. Bordetella pertussis pertactin antigen Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains pertactin, a membrane-associated antigen of Bordetella pertussis . Selenic acid An ingredient found in a variety of supplements and vitamins. Calcium citrate An ingredient found in a variety of supplements and vitamins. Selenium An ingredient found in a variety of supplements and vitamins. Zeaxanthin Zeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some... Lycopene An ingredient found in a variety of supplements and vitamins. Tocopherol Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and... Xanthan gum Xanthan gum is a polysaccharide gum derived from* Xanthomonas campestris* by a pure-culture fermentation process and purified by recovery with isopropyl alcohol. The major constituents include D-glucose, D-mannose, and D-glucuronic... Thrombin A coagulation factor used to stop bleeding during surgery. Prothrombin A coagulation factor used for emergency reversal of vitamin K antagonist therapy. Soy sterol Not Annotated Factor IX Complex (Human) A Factor IX complex used to prevent and treat bleeding episodes in hemophilia B or vitamin K antagonist therapy. Fenprostalene Not Annotated Luprostiol Not Annotated Prostalene Analog of prostaglandin F2 alpha. Cloprostenol Not Annotated Fluprostenol Not Annotated Eftrenonacog alfa A recombinant Factor IX used to treat and prevent bleeding in hemophilia B. Epoetin delta Epoetin Delta is an ingredient in the EMA-withdrawn product Dynepo. Temoporfin A photosensitizer used to treat squamous cell carcinomas of the head and neck. Eptotermin alfa A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. Eptotermin alfa is an ingredient in... Dibotermin alfa indicated for the treatment of acute tibia fractures in adults, as an adjunct to standard care using open fracture reduction and intramedullary unreamed nail fixation [FDA Label]. indicated for single-level... Recombinant Cholera Toxin B Subunit Recombinant Cholera Toxin B Subunit is an ingredient in the EMA-authorised product Dukoral. Rebamipide A gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa. Latanoprostene bunod A prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma. Rusalatide acetate Chrysalin has been used in trials studying the treatment of Radius Fracture. Bombesin Bombesin is under investigation in clinical trial NCT01205321 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Tolerability and Diagnostic Performance of BAY86-7548 in Patients With Prostate Cancer and... Endostar Endostar is under investigation for the treatment of Nasopharyngeal Carcinoma. Endostar has been investigated for the treatment of Non-small Cell Lung Cancer. Allicin Allicin has been used in trials studying the treatment of Follicular Lymphoma. Talaporfin Talaporfin has been investigated for the treatment of Port-Wine Stain and Benign Prostatic Hyperplasia. Dinitrochlorobenzene Dinitrochlorobenzene has been used in trials studying the treatment of HIV Infections. Leukotriene D4 Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis. Crocin Crocin has been investigated for the treatment of Hyperglycemia, Metabolic Syndrome, Hypertriglyceridemia, and Hypercholesterolemia. Avotermin Juvista has been investigated for the treatment, prevention, and basic science of Scars, Keloid, and Cicatrix. Interleukin-7 Interleukin 7 has been used in trials studying the treatment of Metastatic Breast Cancer. Nagrestipen Nagrestipen has been used in trials studying the treatment of CANCER, Neoplasm, Metastasis, Radiation Oncology, and Neoplasm Metastasis. Zuretinol acetate Zuretinol acetate has been used in trials studying the treatment of Impaired Dark Adaptation, RP (Retinitis Pigmentosa), Retinitis Pigmentosa (RP), and LCA (Leber Congenital Amaurosis). Epigallocatechin gallate Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. Bradykinin Bradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2. Bucillamine Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis. Binetrakin Binetrakin has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, Non-Hodgkin's Lymphoma (NHL), Myelodysplastic Syndrome (MDS), and Leukemia, Acute Myelogenous (AML), among others. Dulanermin Dulanermin has been used in trials studying the treatment of Colorectal Cancer, Non-Hodgkin's Lymphoma, and Metastatic Colorectal Cancer. Vatreptacog alfa Vatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors. Muplestim Muplestim is under investigation in clinical trial NCT00002258 (A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in... Tempol Tempol has been used in trials studying the treatment of Anal Cancer. Propyl Gallate Propyl Gallate is under investigation in clinical trial NCT01450098 (A Study of LY2484595 in Healthy Subjects). Muscimol Muscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease. Molgramostim Molgramostim has been used in trials studying the treatment of Bronchiectasis, Cystic Fibrosis, Pulmonary Alveolar Proteinosis, Acute Respiratory Distress Syndrome, and Autoimmune Pulmonary Alveolar Proteinosis. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Sprifermin Sprifermin has been used in trials studying the treatment of Osteoarthritis, Knee and Cartilage Injury of Knee. Apocynin Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease. Nerve Growth Factor Nerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, Alzheimer's Disease, Traumatic Brain Injury, Cerebral Palsy Children, and Delayed Speech Development, among others. Tocotrienol Tocotrienol has been investigated for the treatment of Cholesterol Lowering. Endothelin-1 Endothelin 1 is under investigation in clinical trial NCT00745693 (The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin). Balugrastim Balugrastim has been used in trials studying the treatment of Solid Tumors. Sulprostone A prostaglandin analogue used to treat post-partum hemorrhaging, induce medical abortion, and induce labour in instances of in utero fetal death. Hydroxytyrosol Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer. Dinoprost A medication used to induce a second trimester abortion. Naptumomab estafenatox Naptumomab Estafenatox has been used in trials studying the treatment of Pancreatic Cancer, Renal Cell Carcinoma, and Non-Small-Cell Lung Carcinoma. Interleukin-10 Interleukin-10 has been used in trials studying the prevention and treatment of Vasculitis, Pancreatitis, Bile Duct Diseases, Pancreatic Diseases, and Gallbladder Diseases, among others. Factor XIII (human) A purified form of Factor XIII that is used to prevent and treat surgical bleeding in patients with a Factor XIII deficiency. Leukotriene B4 Leukotriene B4 has been used in trials studying the treatment of HIV Infections. Neosaxitoxin Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic). Acteoside Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy). Tirilazad Tirilazad has been used in trials studying the treatment of Spinal Cord Injury. Chromanol Chromanol has been used in trials studying the treatment of Prostate Cancer. Von Willebrand factor human A blood clotting factor used to manage bleeding episodes in von Willebrand disease and hemophilia A,. Lenograstim A granulocyte colony-stimulating factor indicated in the reduction of duration of neutropenia in bone marrow transplant and cytotoxic chemotherapy, as well as mobilizing hematopoietic stem cells in healthy donors. Coagulation factor X human A coagulation factor used to treat Factor X deficiency to control bleeding. Protein S human A medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy. Coagulation factor VII human A coagulation factor used to treat bleeding disorders such as hemophilia and Glanzmann's thrombasthenia. Anti-inhibitor coagulant complex A medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B. Coagulation Factor IX Human A coagulation factor used to treat hemophilia B or factor IX hemophilia. Kallidinogenase Not Annotated Lipegfilgrastim A medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy. Trenonacog alfa Human coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced in CHO cells. Motretinide Not Annotated Hematin Not Annotated Iprazochrome Not Annotated Enprostil Not Annotated Albutrepenonacog alfa A recombinant Factor IX fused to recombinant human albumin used to treat hemophilia B. Meningococcal polysaccharide vaccine group C Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified from Neisseria meningitidis serogroup C. N. meningitidis is a bacteria that causes endemic and epidemic diseases including meningitis and... Cenegermin A recombinant human nerve growth factor used to treat neurotrophic keratitis. Nonacog beta pegol A recombinant coagulation Factor IX derivative used to treat hemophilia B. Moroctocog alfa A recombinant Factor VIII used to treat hemophilia A to control bleeding. alpha-Tocopherol succinate A form of vitamin E used to treat and prevent vitamin deficiencies. D-alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. Sodium bisulfite An ingredient in parenteral nutrition products for patients with severe liver disorders. beta-Sitosterol Active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. Interleukin-1 alpha, human recombinant Not Annotated Tocopherylquinone Not Annotated 13-cis-12-(3'-Carboxyphenyl)retinoic acid Not Annotated Basic Fibroblast Growth Factor Basic Fibroblast Growth Factor is not currently approved for any FDA or Health Canada approved indications. Nepidermin Not Annotated N,N'-diphenyl-1,4-phenylenediamine Not Annotated 4-(Isopropylamino)diphenylamine 4-(Isopropylamino)diphenylamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Bilberry Not Annotated Turmeric Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Insulin-like growth factor II The insulin-like growth factor II is a well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. This factor presents effects related to growth... Beroctocog alfa Beroctocog alfa is indicated for the prevention and control of bleeding in patients with hemophilia A or acquired Factor VIII (FVIII) deficiency. It is also indicated for surgical/invasive procedures in... Sodium ascorbate Not Available Calcium ascorbate Not Available Magnesium ascorbate Not Available Ferrous ascorbate A medication used to treat iron-deficiency anemia. Andexanet alfa A recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban. Riboflavin tetrabutyrate Not Annotated Peginterferon lambda-1a Peginterferon lambda-1a is under investigation in clinical trial NCT01754974 (Safety and Efficacy Study of Peginterferon Lambda-1a vs. Peginterferon Alfa-2a, Plus Ribavirin in Subjects With Genotype 1 Hepatitis C). Human interleukin-2 Human interleukin-2 is under investigation in clinical trial NCT03475134 (TIL-ACT After NMA Chemo With IL-2 and Nivo Rescue in mMEL). Eflapegrastim A form of recombinant human granulocyte colony stimulating factor used to induce the production of granulocytes and lower infection risk after myelosuppressive therapy. Recombinant CD40-ligand Recombinant CD40-ligand is under investigation in clinical trial NCT00053391 (Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma). Melanoma antigen recognized by T-cells 1 Melanoma antigen recognized by T-cells 1 is under investigation in clinical trial NCT01748747 (Vaccine Therapy and Resiquimod in Treating Patients With Stage II-IV Melanoma That Has Been Removed By Surgery). Leridistim Leridistim is under investigation in clinical trial NCT00004215 (Leridistim Compared With Filgrastim in Treating Older Patients With Acute Myeloid Leukemia). Dexpramipexole Dexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of... Interferon alfa-2c Interferon alfa-2c is under investigation in clinical trial NCT00485563 (A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive Metastatic Renal Cell Carcinoma). Bempegaldesleukin Bempegaldesleukin is under investigation in clinical trial NCT03729245 (A Study of NKTR-214 in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib... Pegilodecakin Pegilodecakin is under investigation in clinical trial NCT03382912 (Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer). Norbixin Norbixin is under investigation in clinical trial NCT03820245 (Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals). Chlorotoxin Chlorotoxin is under investigation in clinical trial NCT00733798 (A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma). Marzeptacog alfa (activated) Marzeptacog alfa (activated) is under investigation in clinical trial NCT01439971 (Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia). Dihematoporphyrin ether Dihematoporphyrin ether is under investigation in clinical trial NCT00118222 (High Light and Low Light Dose PDT in Glioma). Pegbelfermin Pegbelfermin is under investigation in clinical trial NCT03486899 (A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis). Tozuleristide Tozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery). ALT-801 ALT-801 is under investigation in clinical trial NCT01478074 (ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia). Teceleukin Teceleukin is under investigation in clinical trial NCT03610490 (Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Osteosarcoma, or Pancreatic Ductal Adenocarcinoma). gamma-Tocopherol gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). Tucotuzumab celmoleukin Tucotuzumab celmoleukin is under investigation in clinical trial NCT00016237 (Interleukin-2 Combined With Monoclonal Antibody Therapy in Treating Patients With Kidney, Bladder, or Lung Cancer That Has Not Responded to Previous... Coagulation factor XIa Coagulation factor XIa is under investigation in clinical trial NCT01701947 (HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency). Lorukafusp alfa Lorukafusp alfa is under investigation in clinical trial NCT01334515 (Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma). Fucoxanthin Fucoxanthin is under investigation in clinical trial NCT03613740 (Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion). Fucoxanthin isis a marine carotenoid mainly found... Patulin Not Annotated Edodekin alfa Edodekin alfa is under investigation in clinical trial NCT01468896 (Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That Is Recurrent, Metastatic, or... Droloxifene Droloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more... BNT162b1 SARS-CoV-2 Vaccine BNT162b1 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002, L15007] BNT162b1 is a nucleoside modified mRNA (modRNA) vaccine encoding... Tozinameran An mRNA vaccine for the prevention of COVID-19 caused by the SARS-CoV-2 virus. Viral Macrophage-Inflammatory Protein Viral macrophage inflammatory protein-II (vMIP) is a highly basic protein and human chemokine analog encoded by human herpesvirus-8. The structure of vMIP consists of 71 residues and is a monomer... Interferon Kappa Interferon kappa is a subclass of type I interferon mediating host defence which consists of 207 amino acids and has 30% homology with others of the same class as it... Maritime pine extract A plant extract in nutritional supplements for healthy hair, skin, and nails. alpha-Carotene Not Annotated Cryptoxanthin Not Annotated Carbazochrome sulfonic acid A hemostatic agent indicated to treat bleeding in capillary fragility. Garlic oil Not Annotated Rurioctocog alfa pegol A pegylated recombinant human coagulation factor VIII used to treat and prevent bleeding episodes in patients 12 years and above with hemophilia A. Histamine glutarimide Histamine glutarimide is under investigation in clinical trial NCT03450434 (XC8 in the Treatment of Patients With Bronchial Asthma). Aldafermin Aldafermin is under investigation in clinical trial NCT03912532 (Evaluation of Efficacy, Safety and Tolerability of Aldafermin in a Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study in Subjects With Nonalcoholic Steatohepatitis... Baicalein Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of... Bizalimogene ralaplasmid Bizalimogene ralaplasmid is under investigation in clinical trial NCT03499795 (VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 And/or HPV-18 Related Anal or Anal/peri-anal, High Grade... Ecraprost Ecraprost is under investigation in clinical trial NCT00059657 (Efficacy/safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease). Hemoporfin A porphyrin derivative combined with vitamin B12 for the treatment of asthenia. Parathyroid Hormone-Related Protein 1-36 Parathyroid Hormone-Related Protein 1-36 is under investigation in clinical trial NCT00853723 (Comparison Study of Pthrp and PTH to Treat Osteoporosis). Peretinoin Not Annotated Sepiapterin Sepiapterin is under investigation in clinical trial NCT03519711 (A Study of CNSA-001 in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia). Efineptakin alfa Efineptakin alfa (also known as NT-I7) is a long-acting human interleukin-7 (IL-7) fusion protein that promotes T-cell development, contributing to the immune response. Compared to endogenous IL-7, NT-I7 is more... Pidacmeran Pidacmeran is under investigation in clinical trial NCT04380701 (A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-2019 in Healthy Adults). BNT-162A1 BNT-162A1 is under investigation in clinical trial NCT04380701 (A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-2019 in Healthy Adults). EpiVacCorona EpiVacCorona Vaccine, developed by the Vektor State Research Center of Virology and Biotechnology in Russia, is based on peptide-antigens that facilitate immunity to the SARS-CoV-2 virus . It is currently... Tin protoporphyrin IX Not Available Dialyzable leukocyte extract Transferon is comprised of several peptides mixed from human dialyzable leucocyte extracts and acts as an immunomodulator. It is thought to have widespread effects on the immune system, and effective... Vitis vinifera seed Not Annotated Reltecimod Reltecimod is under investigation in clinical trial NCT02469857 (Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections). Tengonermin Tengonermin, also known as NGR-hTNF, is a vascular-targeting drug. It is a recombinant protein and peptide-targeted agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide.... Cytochalasin B Not Annotated Morin Not Annotated Tyrosol Not Annotated Butylated hydroxytoluene Not Annotated Rosmarinic acid Not Annotated Interferon tau Not Annotated Botulinum toxin type F Not Annotated PACAP38 Not Available Redaporfin Not Available SOT-107 Investigated for use/treatment in brain cancer. Disufenton Not Annotated Heme arginate Not Available MDNA-55 Not Annotated - Drugs & Drug Targets