- Gastrointestinal Agents
- Accession Number
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Drug Drug Description Betaine A methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Peppermint oil An ingredient used in a variety of natural health products and is not an approved medication. Pancrelipase A purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis. Glucagon A form of recombinant glucagon used to treat hypoglycemia in diabetes mellitus and as a part of gastrointestinal imaging procedures. Infliximab A monoclonal anti tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis. Octreotide A peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors. Choline A nutrient found in a wide variety of vitamins including pre-natal formulations. Lorazepam A long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Pantoprazole A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. Betazole For use clinically to test gastric secretory function. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Omeprazole A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. Sucralfate A gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence. Doxylamine An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy. Thiethylperazine A drug used for the treatment of nausea and vomiting. Promazine A phenothiazine used to manage schizophrenia. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Cyproheptadine A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Lactulose A disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy. Nizatidine An H2 receptor antagonist used to treat GERD and a variety of ulcers. Cisapride A medication used to treat heartburn associated with GERD. Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis. Pirenzepine An antimuscarinic agent used to treat peptic ulcers, gastric ulcers, and duodenal ulcers. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Esomeprazole A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. Meclizine A histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Propantheline An antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder. Sulfasalazine An anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. Ranitidine A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis. Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. Famotidine A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. Misoprostol A prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers. Methylprednisolone A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases. Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness. Balsalazide An aminosalicylate used to treat ulcerative colitis. Diphenhydramine A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Diphenoxylate An antidiarrheal medication used with atropine to manage diarrhea. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Cyclizine An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Rifaximin A rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults. Diphenidol An antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Dexamethasone A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. Olsalazine An anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis. Bismuth subsalicylate An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Magnesium oxide A compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health. Alizapride A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies. Kaolin A natural ingredient used for the short-term symptomatic treatment of various conditions including diarrhea, skin dryness, and minor skin bleeding. Ursodeoxycholic acid A bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. Sorbitol A product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. Sucrosofate Not Available Carbenoxolone A drug used to symptomatically treat lip sores and mouth ulcers. Naringenin Not Available Deoxycholic acid A cytolytic agent injected subcutaneously to improve the appearance submental fat. Taurocholic acid The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats... Dantron Withdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity. Oxyphenisatin A laxative that undergoes enterohepatic circulation. It may cause jaundice. Sofalcone Investigated for use/treatment in gastroenteritis and ulcers. Ecabet For the treatment of reflux oesophagitis and peptic ulcer disease. Dexlansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. AZD 3355 Investigated for use/treatment in gastroesophageal reflux disease (GERD). Alicaforsen Investigated for use/treatment in crohn's disease and ulcerative colitis. Alvimopan An opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis. Dexanabinol Investigated for use/treatment in traumatic brain injuries and neurologic disorders. Casopitant Investigated for use/treatment in urinary incontinence and adverse effects (chemotherapy). Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy. Aluminum hydroxide An antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach. Calcium carbonate An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach. Chenodeoxycholic acid A bile acid used for the treatment of primary biliary cirrhosis. Cupric sulfate A compound used as an intravenous copper supplement for Total Parenteral Nutrition (TPN). Ferulic acid Not Available Metiamide Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. Roxatidine acetate For the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also... Taurochenodeoxycholic acid Taurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy. Tauroursodeoxycholic acid Used in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis,... Cholecystokinin For use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency . Teduglutide A glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support. Magaldrate An antacid used to treat various conditions in the GI tract, such as esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Bisacodyl A stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults. Vedolizumab An integrin blocker and anti-inflammatory agent used to manage ulcerative colitis and Crohn's disease in adults with inadequate clinical response to immunomodulators. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Magnesium hydroxide An inorganic compound used as a laxative and antacid. Polaprezinc Peptic ulcer disease, dyspepsia . Picosulfuric acid A stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults. Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea. Magnesium trisilicate An antacid used for the symptomatic treatment of peptic ulcers. Polyethylene glycol A laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures. Ramosetron A selective 5-HT3 antagonist used as an antiemetic for chemotherapy- and postoperative-associated nausea and vomiting. It may also possess efficacy in irritable bowel syndrome. Polycarbophil Polycarbophil is used to treat constipation and to help maintain regular bowel movements. Sodium sulfate An agent used for bowel cleansing prior to colonoscopy or barium enema X-ray examination. Secretin porcine A secretin hormone used to stimulate pancreatic or gastric secretions to diagnose exocrine pancreas dysfunction, gastrinoma, and abnormalities in the bile and pancreatic ducts. Carob An extract from Carob used in allergy testing. Carboxymethylcellulose A compound used as an ophthalmic lubricant. Plantago seed An ingredient used in a variety of natural health products. Magnesium citrate A laxative used in bowel preparation for colonoscopy or as a magnesium supplement. Castor oil An ingredient used in a variety of natural health products. Opium A medication used to treat moderate to severe pain. Sennosides A laxative used to treat constipation. Poloxalene Ethylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen... Dehydrocholic acid No approved therapeutic indications. Rebamipide A gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. Racecadotril An anti-secretory enkephalinase inhibitor useful in the treatment of diarrhea. Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. BPC-157 Bepecin is under investigation in clinical trial NCT02637284 (PCO-02 - Safety and Pharmacokinetics Trial). Lesogaberan Lesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others. Gefarnate Gefarnate has been investigated for the treatment and prevention of Stomach Ulcer, Duodenal Ulcer, and Cardio-cerebrovascular Disease. Vofopitant Vofopitant has been used in trials studying the treatment of PTSD, Primary Insomnia, and Sleep Initiation and Maintenance Disorders. Lafutidine Lafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD). Pancreatic Polypeptide Pancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1. Lactitol An orally administered osmotic laxative used to treat chronic idiopathic constipation. Irsogladine Irsogladine is under investigation in clinical trial NCT02581696 (The Drug-drug Interaction and Safety of Lafutidine and Irsogladine Maleate in Healthy Adult Volunteers). Pepsin A protease indicated in the treatment of digestive disorders. Bismuth subnitrate A medication used as an antacid. Ipecac An emetic agent used to induce vomiting in poisoning. Sulglicotide Not Annotated Hydrotalcite An antacid indicated in the treatment of heartburn and excess gastric acid. Emetine Not Annotated Proglumide Not Annotated Otilonium A spasmolytic medication used to treat irritable bowel syndrome (IBS). Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy. Metopimazine Not Annotated Dexrabeprazole A proton pump inhibitor indicated in the treatment of gastroesophageal reflux disease and gastrointestinal ulcers. Dixyrazine Not Annotated Epomediol Not Annotated Enprostil Not Annotated Glutamic acid An amino acid commonly found as a component in total parenteral nutrition. Papain A proteolytic enzyme derived from papaya used for its anti-inflammatory properties. Bromelains A protease indicated in the treatment of inflammation and for eschar removal. Tilactase A beta-D-galactosidase use to treat lactose intolerance. Anethole trithione A medication used to treat dry mouth associated with medication or radiotherapy of the head and neck. Aluminium phosphate Not Available Secretin human A secretin hormone used to stimulate pancreatic or gastric secretions to diagnose exocrine pancreas dysfunction, gastrinoma, and abnormalities in the bile and pancreatic ducts. Plantago ovata seed A plant extract indicated in the treatment of occasional constipation. Oxyphenisatin acetate Not Annotated Calcium polycarbophil A bulk forming laxative used to treat constipation. Glycocholic acid The glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Emodin Emodin has been investigated for the treatment of Polycystic Kidney. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Konjac mannan Konjac mannan is under investigation in clinical trial NCT01709955 (The Effects of Glucomannan on Weight Loss). Gastric inhibitory polypeptide Gastric inhibitory polypeptide is under investigation in clinical trial NCT03081676 (The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea). Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Scopolamine A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV). Prucalopride A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Catumaxomab For use in the management of malignant ascites tumours via intraperitoneal infusion where standard therapy is not available or feasible [FDA Label]. Cinitapride It is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying. Linaclotide A guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature. Maropitant Maropitant, used as maropitant citrate, is a neurokinin receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by... Etrolizumab Etrolizumab has been used in trials studying the treatment of Crohn Disease and Ulcerative Colitis. Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. Pirnabine Pirnabine has been used in trials studying the treatment of Chronic Idiopathic Constipation. Dolcanatide Dolcanatide has been investigated in Exposure. Plecanatide A laxative used to treat chronic idiopathic constipation and IBS with constipation. Loperamide oxide Not Annotated Alloin Not Annotated Frangula purshiana bark Not Annotated Pancrelipase lipase A lipase used to treat pancreatic exocrine insufficiency. Teprenone A medication indicated in the treatment of acute gastroenteritis, exacerbations of gastric inflammation, and gastric ulcers. Praliciguat Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)). Bismuth subcitrate potassium A colloid used for the treatment of peptic ulcer and gastro-esophageal reflux disease (GERD).
- Drugs & Drug Targets