This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Alloin
DrugBank Accession Number
DB15477
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
Thumb
Weight
Average: 418.398
Monoisotopic: 418.126382288
Chemical Formula
C21H22O9
Synonyms
  • Aloin
  • Aloin, Cape
  • Aloin, curaco

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Alloin.
AclidiniumThe therapeutic efficacy of Alloin can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Alloin can be decreased when used in combination with Alfentanil.
AmantadineThe therapeutic efficacy of Alloin can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Alloin.
AmiodaroneThe therapeutic efficacy of Alloin can be decreased when used in combination with Amiodarone.
AmitriptylineThe therapeutic efficacy of Alloin can be decreased when used in combination with Amitriptyline.
AmlodipineThe therapeutic efficacy of Alloin can be decreased when used in combination with Amlodipine.
AmobarbitalThe therapeutic efficacy of Alloin can be decreased when used in combination with Amobarbital.
AmoxapineThe therapeutic efficacy of Alloin can be decreased when used in combination with Amoxapine.
Interactions
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Food Interactions
Not Available

Products

Products2
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Aid-lax TabAlloin (12 mg / tab) + Frangula purshiana bark (30 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab)TabletOralNobel Pharm Enr.1989-12-311997-07-31Canada flag
AlsilineAlloin (12 mg / tab) + Frangula purshiana bark (30 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab)TabletOralAlsi Cie Ltee1978-12-311997-08-08Canada flag
Bicholate Lilas TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralSabex Inc1991-12-311997-10-10Canada flag
Bilex TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralBiodo Enrg1978-12-311997-10-10Canada flag
Carters Little Pills TabAlloin (8 mg / tab) + Phenolphthalein (16 mg / tab)TabletOralCarter Products, Division Of Carter Wallace Ns Inc.1978-12-311997-08-14Canada flag
Lax-BO TabAlloin (12 mg / tab) + Frangula purshiana bark (30 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab)TabletOralCardinaux Medicinat Inc.1992-12-311996-09-09Canada flag
Laxatif TabAlloin (12 mg / tab) + Frangula purshiana bark (30 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab)TabletOralVitalab1991-12-311997-12-18Canada flag
Laxative TabAlloin (12 mg / tab) + Frangula purshiana bark (30 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab)TabletOralLaboratoire Lalco Inc.1978-12-311997-10-10Canada flag
Laxavite TabAlloin (12 mg / tab) + Frangula purshiana bark (30 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab)TabletOralNeosol Enrg1978-12-311997-07-29Canada flag
Robol TabAlloin (16.2 mg / tab) + Belladonna (5.4 mg / tab) + Ipecac (4.32 mg / tab) + Phenolphthalein (64.8 mg / tab)TabletOralLabs Anglo French1979-12-311997-08-05Canada flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
W41H6S09F4
CAS number
8015-61-0
InChI Key
AFHJQYHRLPMKHU-CGISPIQUSA-N
InChI
InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14?,17-,19+,20-,21+/m1/s1
IUPAC Name
1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(CO)C=C2O

References

General References
Not Available
ChemSpider
8042387
BindingDB
50269016
RxNav
17354
ChEBI
73222
ChEMBL
CHEMBL497001
Wikipedia
Aloin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.63 mg/mLALOGPS
logP-0.49ALOGPS
logP0.41ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)8.31ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area167.91 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity103.79 m3·mol-1ChemAxon
Polarizability40.97 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at August 30, 2019 15:38 / Updated at June 12, 2020 16:53