- Natriuretic Agents
- Accession Number
Endogenous or exogenous chemicals that regulate the WATER-ELECTROLYTE BALANCE in the body. They consist of peptides and non-peptide compounds.
Drug Drug Description Desmopressin A synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia. Vasopressin A peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy. Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Ethoxzolamide For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. Triamterene A potassium-sparing diuretic used in the treatment of edema and in the management of hypertension. Spironolactone An aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. Cyclothiazide Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either... Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Methazolamide A carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Acetazolamide A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. Chlorothiazide A thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Etacrynic acid A diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. Hydrochlorothiazide A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Trichlormethiazide Used in the treatment of oedema (including that associated with heart failure) and hypertension. Polythiazide A thiazide diuretic used in the management of hypertension and treatment of edema. Drospirenone A progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions. Piretanide A loop diuretic used to manage essential arterial hypertension and edema cardiac, hepatic, and renal origin. Nesiritide A recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. Ularitide Investigated for use/treatment in congestive heart failure. Azosemide Azosemide is a loop diuretic used to treat hypertension, edema, and ascites. Potassium citrate An agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones. Isosorbide A vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It was previously used to reduce intraocular pressure. Rolofylline Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure. Cicletanine Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension. Mefruside Not Annotated Fenquizone Not Annotated Clopamide Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure. Buthiazide A diuretic indicated in the treatment of edema caused by congestive heart failure, as well as hepatic and renal diseases. Metolazone A thiazide-like diuretic used to treat hypertension. Amiloride A pyrizine compound used to treat hypertension and congestive heart failure. Tienilic acid For the treatment of hypertension. Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Methyclothiazide A diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy. Bendroflumethiazide A diuretic used to suppress lactation and to treat hypertension and edema. Eplerenone An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Canrenoic acid An aldosterone antagonist used in primary hyperaldosteronism and other disorders related to aberrant aldosterone levels. Efonidipine For the treatment of hypertension. Canrenone An antimineralocorticoid and active metabolite of spironolactone used in the treatment of primary hyperaldosteronism and edematous states caused by secondary hyperaldosteronism (e.g. heart failure). Spiradoline Spiradoline has been investigated for the basic science of Bipolar Depression. Cyclopenthiazide Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients... Muzolimine Not Annotated Xipamide A diuretic indicated in the treatment of edema. Mannitol A sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis. Conivaptan An antidiuretic hormone inhibitor used to raise serum sodium levels. Quinethazone Used to treat hypertension. Tolvaptan A selective vasopressin V2-receptor antagonist to slow kidney function decline in patients at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). Also used to treat hypervolemic and euvolemic hyponatremia. Lypressin Not Annotated Balovaptan Balovaptan is under investigation in clinical trial NCT01793441 (A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD)). Satavaptan Satavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver). Tripamide Not Annotated
- Drugs & Drug Targets