- Natriuretic Agents
- Accession Number
Endogenous or exogenous chemicals that regulate the WATER-ELECTROLYTE BALANCE in the body. They consist of peptides and non-peptide compounds.
Drug Drug Description Desmopressin A synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia. Vasopressin A peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy. Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Methyclothiazide A diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy. Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Ethoxzolamide For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. Triamterene A potassium-sparing diuretic used in the treatment of edema and in the management of hypertension. Spironolactone An aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. Bendroflumethiazide A diuretic used to suppress lactation and to treat hypertension and edema. Metolazone A thiazide-like diuretic used to treat hypertension. Amiloride A pyrizine compound used to treat hypertension and congestive heart failure. Cyclothiazide Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either... Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Eplerenone An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. Methazolamide A carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. Mannitol A sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Acetazolamide A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. Conivaptan An antidiuretic hormone inhibitor used to raise serum sodium levels. Chlorothiazide A thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Etacrynic acid A diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. Hydrochlorothiazide A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Trichlormethiazide Used in the treatment of oedema (including that associated with heart failure) and hypertension. Polythiazide A thiazide diuretic used in the management of hypertension and treatment of edema. Quinethazone Used to treat hypertension. Drospirenone A progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions. Piretanide A loop diuretic used to manage essential arterial hypertension and edema cardiac, hepatic, and renal origin. Tienilic acid For the treatment of hypertension. Nesiritide A recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. Ularitide Investigated for use/treatment in congestive heart failure. Tolvaptan A selective vasopressin V2-receptor antagonist to slow kidney function decline in patients at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). Also used to treat hypervolemic and euvolemic hyponatremia. Azosemide Azosemide is a loop diuretic used to treat hypertension, edema, and ascites. Canrenoic acid An aldosterone antagonist used in primary hyperaldosteronism and other disorders related to aberrant aldosterone levels. Potassium citrate An agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones. Efonidipine For the treatment of hypertension. Isosorbide A vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It was previously used to reduce intraocular pressure. Canrenone An antimineralocorticoid and active metabolite of spironolactone used in the treatment of primary hyperaldosteronism and edematous states caused by secondary hyperaldosteronism (e.g. heart failure). Rolofylline Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure. Spiradoline Spiradoline has been investigated for the basic science of Bipolar Depression. Cicletanine Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension. Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Mefruside Not Annotated Cyclopenthiazide Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients... Fenquizone Not Annotated Clopamide Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure. Muzolimine Not Annotated Xipamide A diuretic indicated in the treatment of edema. Lypressin Not Annotated Satavaptan Satavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver). Buthiazide A diuretic indicated in the treatment of edema caused by congestive heart failure, as well as hepatic and renal diseases. Tripamide Not Annotated
- Drugs & Drug Targets