Cholestanes

Name
Cholestanes
Accession Number
DBCAT000308
Description

Derivatives of the saturated steroid cholestane with methyl groups at C-18 and C-19 and an iso-octyl side chain at C-17.

Drugs
DrugDrug Description
CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
AlfacalcidolA vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure, as well as some types of rickets and osteomalacia.
Fusidic acidA topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.
Soy sterolNot Annotated
CholecalciferolA form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
ParicalcitolA vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
1alpha,24S-Dihydroxyvitamin D2Investigated for use/treatment in parathyroid disorders.
DoxercalciferolA synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
Cholesteryl chlorideCholesteryl chloride, also known as 3-chlorocholest-5-ene, is an organochloride derivative of cholesterol. It is presented as a liquid crystal that forms clockwise liquid crystals.
CalcifediolAn active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
DihydrotachysterolA synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
Cholesterol sulfateComponent of human seminal plasma & spermatozoa.
Cholesteryl LinoleateNot Available
CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
LexacalcitolLexacalcitol is a solid. This compound belongs to the vitamin D and derivatives class of chemicals. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane. It is known...
LanosterolNot Available
ErgosterolA steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...
SeocalcitolNot Available
20-hydroxycholesterolNot Available
25-HydroxycholesterolNot Available
7beta-hydroxycholesterolNot Available
InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
BecocalcidiolFor topical treatment of psoriasis and psoriatic disorders.
TRO19622Investigated for use/treatment in neurologic disorders.
CaprospinolAlzheimer's Disease
SmilageninInvestigated for use/treatment in alzheimer's disease, parkinson's disease and other neurodegenerative diseases.
ElocalcitolInvestigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
MaxacalcitolNot Annotated
SqualamineInvestigated for use/treatment in ovarian cancer, lung cancer, and macular degeneration.
1alpha-Hydroxyvitamin D51alpha-Hydroxyvitamin D5 (CARD-024) has been used in trials studying the treatment of Drug Safety and Heart; Disease, Activity.
Iodine (131I) norcholesterolA radioiodine-labeled cholesterol analogue that accumulates in areas where steroid hormones are produced and is used in certain diagnostic procedures.
TacalcitolA vitamin D analog indicated in the treatment of mild to moderate plaque psoriasis.
beta-SitosterolActive fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.
24-Homo-1,25-dihydroxyvitamin D324-Homo-1,25-dihydroxyvitamin D3 is a novel vitamin D analogue.
Previtamin D(3)Not Annotated
RuscogeninAn anti-inflammatory steroid used in combination with local anesthetics for the treatment of hemorrhoids and for local anesthesia.
Drugs & Drug Targets
DrugTargetType
CalcitriolVitamin D3 receptortarget
Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CalcitriolCytochrome P450 3A4enzyme
CalcitriolHomeobox protein Hox-A10target
CalcitriolVitamin D-binding proteincarrier
AlfacalcidolVitamin D-binding proteincarrier
AlfacalcidolVitamin D3 receptortarget
Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
AlfacalcidolRetinoic acid receptor RXR-alphatarget
AlfacalcidolAlpha globincarrier
Fusidic acidChloramphenicol acetyltransferase 3target
Fusidic acidChloramphenicol acetyltransferasetarget
Fusidic acidBile salt export pumptransporter
Fusidic acidCanalicular multispecific organic anion transporter 1transporter
Fusidic acidElongation factor Gtarget
Fusidic acidCytochrome P450 2D6enzyme
Fusidic acidCytochrome P450 3A4enzyme
Fusidic acidUDP-glucuronosyltransferase 1-1enzyme
Fusidic acidATP-binding cassette sub-family G member 2transporter
Fusidic acidSolute carrier organic anion transporter family member 1B1transporter
CholecalciferolVitamin D-binding proteincarrier
CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
CholecalciferolVitamin D 25-hydroxylaseenzyme
CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
CholecalciferolCytochrome P450 2J2enzyme
CholecalciferolCytochrome P450 3A4enzyme
CholecalciferolVitamin D3 receptortarget
CholecalciferolCytochrome P450 1A1enzyme
CholecalciferolCytochrome P450 2C8enzyme
ParicalcitolVitamin D3 receptortarget
Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
ParicalcitolCytochrome P450 3A4enzyme
ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
CholesterolNuclear receptor ROR-alphatarget
CholesterolP-glycoprotein 1transporter
CholesterolATP-binding cassette sub-family G member 2transporter
CholesterolNuclear receptor subfamily 1 group I member 3target
CholesterolVitamin D3 receptortarget
CholesterolC-type lectin domain family 4 member Etarget
DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DoxercalciferolVitamin D3 receptortarget
Calcifediol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
CalcifediolVitamin D3 receptortarget
Calcifediol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DihydrotachysterolVitamin D3 receptortarget
Cholesterol sulfateNuclear receptor ROR-alphatarget
Cholesteryl LinoleateLipase 3target
CalcipotriolVitamin D3 receptortarget
CalcipotriolMyeloperoxidaseenzyme
Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
LexacalcitolVitamin D3 receptortarget
LanosterolLanosterol synthasetarget
SeocalcitolVitamin D3 receptortarget
InecalcitolVitamin D3 receptortarget
BecocalcidiolMediator of RNA polymerase II transcription subunit 1target
BecocalcidiolVitamin D3 receptortarget
ElocalcitolVitamin D3 receptortarget