Sulfhydryl Compounds

Name
Sulfhydryl Compounds
Accession Number
DBCAT000316
Description

Compounds containing the -SH radical.

Drugs
DrugDrug Description
AzathioprineAn immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
MercaptopurineAn antineoplastic agent used to treat acute lymphocytic leukemia.
AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
Coenzyme MA uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.
CarbocisteineA expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.
CysteineAn amino acid commonly found as a component of total parenteral nutrition and used as an antidote for acetaminophen overdose.
SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
MercaptoethanolNot Available
Dimercaptosuccinic acidNot Annotated
CysteamineA cystine depleting agent used to treat the effects of cystinosis.
S-MethylcysteineNot Available
Cysteine-S-acetamideNot Available
S-PhosphocysteineNot Available
D-pantetheine 4'-phosphateNot Available
ButyrylthiocholineA sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem]
S-sulphocysteineNot Available
S-BenzylcysteineNot Available
ErdosteineA mucolytic agent used to treat conditions characterized by pathological mucus such as respiratory tract infections and chronic obstructive pulmonary disease (COPD).
AlethineInvestigated for use/treatment in blood (blood forming organ disorders, unspecified), lymphoma (unspecified), and multiple myeloma.
Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
Technetium Tc-99m succimerA radioactive diagnostic agent used as an aid in the scintigraphic evaluation of renal parenchymal disorders.
PantethineA naturally occurring compound derived from panthothenic acid. It acts as an intermediate in endogenous coenzyme A synthesis and is used as a dietary supplement to treat hypertriglyceridemia.
LesinuradA uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
BucillamineBucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis.
Thioglycolic acidThioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light).
2,3-Dimercapto-1-propanesulfonic acidNot Annotated
Drugs & Drug Targets
DrugTargetType
AzathioprineThiopurine S-methyltransferaseenzyme
AzathioprineXanthine dehydrogenase/oxidaseenzyme
AzathioprineGlutathione S-transferase A1enzyme
AzathioprineGlutathione S-transferase A2enzyme
AzathioprineGlutathione S-transferase Mu 1enzyme
AzathioprineRas-related C3 botulinum toxin substrate 1target
AzathioprineCytochrome P450 1A2enzyme
AzathioprineHypoxanthine-guanine phosphoribosyltransferaseenzyme
AzathioprineNucleotide triphosphate diphosphatase NUDT15enzyme
AzathioprineEquilibrative nucleoside transporter 2transporter
AzathioprineSolute carrier family 28 member 3transporter
AzathioprineP-glycoprotein 1transporter
AzathioprineSolute carrier family 43 member 3transporter
AzathioprineSerum albumincarrier
AzathioprineInosine-5'-monophosphate dehydrogenase 1enzyme
AzathioprineInosine-5'-monophosphate dehydrogenase 2enzyme
AzathioprineGMP synthase [glutamine-hydrolyzing]enzyme
AzathioprineInosine triphosphate pyrophosphataseenzyme
MercaptopurineThiopurine S-methyltransferaseenzyme
MercaptopurineXanthine dehydrogenase/oxidaseenzyme
MercaptopurineHypoxanthine-guanine phosphoribosyltransferasetarget
MercaptopurineSolute carrier family 22 member 8transporter
MercaptopurineMultidrug resistance-associated protein 4transporter
MercaptopurineMultidrug resistance-associated protein 5transporter
MercaptopurineSodium/nucleoside cotransporter 2transporter
MercaptopurineSolute carrier family 28 member 3transporter
MercaptopurineEquilibrative nucleoside transporter 1transporter
MercaptopurineEquilibrative nucleoside transporter 2transporter
MercaptopurineAldehyde oxidaseenzyme
MercaptopurineAmidophosphoribosyltransferasetarget
MercaptopurineInosine-5'-monophosphate dehydrogenasetarget
AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
AcetylcysteineSolute carrier family 22 member 6transporter
AcetylcysteineAminoacylase-1target
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
AcetylcysteineGlutathione synthetasetarget
AcetylcysteineCystine/glutamate transportertarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
AcetylcysteineSerum albumincarrier
AcetylcysteineAminoacylase-1enzyme
DimercaprolArsenictarget
DimercaprolCadmiumtarget
DimercaprolMercurytarget
DimercaprolAmyloid beta A4 proteintarget
CarbocisteineCysteine dioxygenase type 1enzyme
CarbocisteinePhenylalanine-4-hydroxylaseenzyme
CarbocisteinePI-PLC X domain-containing protein 3target
CarbocisteineLactosylceramide alpha-2,3-sialyltransferaseenzyme
CarbocisteineLactosylceramide alpha-2,3-sialyltransferasetarget
CysteineCysteine--tRNA ligase, cytoplasmictarget
CysteineGlutamate--cysteine ligase regulatory subunittarget
CysteineGlutamate--cysteine ligase catalytic subunittarget
CysteineAspartate aminotransferase, cytoplasmictarget
CysteineCystathionine gamma-lyasetarget
CysteineCystathionine beta-synthasetarget
CysteineCysteine dioxygenase type 1target
CysteineMethylated-DNA--protein-cysteine methyltransferasetarget
CysteineGlutathione synthetasetarget
CysteineProbable cysteine--tRNA ligase, mitochondrialtarget
CysteineCysteine sulfinic acid decarboxylasetarget
CysteineCysteine desulfurase, mitochondrialtarget
CysteineMonocarboxylate transporter 10transporter
CysteineAspartate aminotransferase, mitochondrialtarget
SuccimerLeadtarget
SuccimerMercurytarget
SuccimerCadmiumtarget
SuccimerArsenictarget
MercaptoethanolLysozymetarget
MercaptoethanolLactoylglutathione lyasetarget
MercaptoethanolPyridoxine-5'-phosphate oxidasetarget
MercaptoethanolGlucose--fructose oxidoreductasetarget
MercaptoethanolAlpha-1-antitrypsintarget
MercaptoethanolPyridoxine/pyridoxamine 5'-phosphate oxidasetarget
MercaptoethanolGalectin-1target
MercaptoethanolProtein ninBtarget
MercaptoethanolPolycomb protein SCMH1target
MercaptoethanolEndonuclease IIItarget
Dimercaptosuccinic acidMercurytarget
Dimercaptosuccinic acidArsenictarget
CysteamineNeuropeptide Y receptor type 2target
CysteamineCystinetarget
CysteamineMyeloperoxidaseenzyme
CysteamineSerum albumincarrier
S-MethylcysteineCathepsin Dtarget
S-MethylcysteineFatty acid-binding protein, livercarrier
S-MethylcysteineMethylated-DNA--protein-cysteine methyltransferasetarget
Cysteine-S-acetamideRibonuclease pancreatictarget
Cysteine-S-acetamide2'-5'-oligoadenylate synthase 1target
S-PhosphocysteineN,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componenttarget
S-PhosphocysteineEnamine/imine deaminasetarget
D-pantetheine 4'-phosphatePhosphopantetheine adenylyltransferasetarget
D-pantetheine 4'-phosphatePhosphopantetheine adenylyltransferasetarget
D-pantetheine 4'-phosphatePhosphopantetheine adenylyltransferasetarget
ButyrylthiocholineCholinesterasetarget
ButyrylthiocholineCholinesteraseenzyme
S-BenzylcysteineMethylated-DNA--protein-cysteine methyltransferasetarget
ErdosteineAdenosine deaminaseenzyme
Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
Technetium Tc-99m succimerSodium-dependent phosphate transporter 1transporter
Technetium Tc-99m succimerSodium-dependent phosphate transporter 2transporter
LesinuradSolute carrier family 22 member 12target
LesinuradSolute carrier family 22 member 11target
LesinuradCytochrome P450 2C9enzyme
LesinuradCytochrome P450 3A4enzyme