Dimercaptosuccinic acid

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Dimercaptosuccinic acid
DrugBank Accession Number
DB14089
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
Thumb
Weight
Average: 182.218
Monoisotopic: 181.97075006
Chemical Formula
C4H6O4S2
Synonyms
  • 2,3-Dimercaptobutanedioic acid
  • 2,3-Dimercaptosuccinic acid
External IDs
  • BRN 1725149

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UMercury
chelator
Humans
UArsenic
chelator
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products
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Product Ingredients
IngredientUNIICASInChI Key
Sodium dimercaptosuccinic acidNot AvailableNot AvailableAITPHKMBHQBXKM-UHFFFAOYSA-L
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Dimercaptosuccinic Acid DMSAInjection, powder, lyophilized, for solution1.1 mg/1IntravenousAnazao Health Corporation2012-07-01Not applicableUS flag
DmsaInjection, powder, lyophilized, for solution1 mg/1IntravenousGe Healthcare2007-08-03Not applicableUS flag
Rotop - DmsaInjection, powder, lyophilized, for solution1 mg/1IntravenousROTOP Pharmaka GmbH2017-08-08Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Dimercaptosuccinic Acid DMSADimercaptosuccinic acid (1.1 mg/1)Injection, powder, lyophilized, for solutionIntravenousAnazao Health Corporation2012-07-01Not applicableUS flag
Rotop - DmsaDimercaptosuccinic acid (1 mg/1)Injection, powder, lyophilized, for solutionIntravenousROTOP Pharmaka GmbH2017-08-08Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as thia fatty acids. These are fatty acid derivatives obtained by insertion of a sulfur atom at specific positions in the chain.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Fatty Acyls
Sub Class
Fatty acids and conjugates
Direct Parent
Thia fatty acids
Alternative Parents
Dicarboxylic acids and derivatives / alpha-Mercaptocarboxylic acids / Alkylthiols / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
2-mercaptocarboxylic acid / Aliphatic acyclic compound / Alkylthiol / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Dicarboxylic acid or derivatives / Hydrocarbon derivative / Organic oxide / Organic oxygen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
4S9JU7XF01
CAS number
2418-14-6
InChI Key
ACTRVOBWPAIOHC-UHFFFAOYSA-N
InChI
InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)
IUPAC Name
2,3-disulfanylbutanedioic acid
SMILES
OC(=O)C(S)C(S)C(O)=O

References

General References
Not Available
Human Metabolome Database
HMDB0014706
ChemSpider
8988
BindingDB
60868
RxNav
2475951
ChEMBL
CHEMBL28721
PharmGKB
PA451521
Wikipedia
Dimercaptosuccinic_acid

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedTreatmentAutism, Early Infantile1
0RecruitingTreatmentWilsons Disease1
Not AvailableCompletedNot AvailablePoisoning, Lead1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous1.1 mg/1
Injection, powder, lyophilized, for solutionIntravenous1 mg/1
Injection, powder, lyophilized, for solutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.43 mg/mLALOGPS
logP0.56ALOGPS
logP0.26ChemAxon
logS-1.9ALOGPS
pKa (Strongest Acidic)3.37ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area74.6 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity38.47 m3·mol-1ChemAxon
Polarizability15.47 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Drugtargets
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Kind
Small molecule
Organism
Humans
Pharmacological action
Unknown
Actions
Chelator
References
  1. Atti SK, Silver EM, Chokshi Y, Casteel S, Kiernan E, Dela Cruz R, Kazzi Z, Geller RJ: All that glitters is not gold: Mercury poisoning in a family mimicking an infectious illness. Curr Probl Pediatr Adolesc Health Care. 2020 Mar 6:100758. doi: 10.1016/j.cppeds.2020.100758. [Article]
Kind
Small molecule
Organism
Humans
Pharmacological action
Unknown
Actions
Chelator
References
  1. Chille D, Cassone G, Giacobello F, Giuffre O, Nardo VM, Ponterio RC, Saija F, Sponer J, Trusso S, Foti C: Removal of As(III) from Biological Fluids: Mono- versus Dithiolic Ligands. Chem Res Toxicol. 2020 Apr 20;33(4):967-974. doi: 10.1021/acs.chemrestox.9b00506. Epub 2020 Mar 24. [Article]

Drug created on June 18, 2018 16:32 / Updated on May 29, 2021 18:15