- Accession Number
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Drug Drug Description Ascorbic acid A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron. Vitamin A A vitamin important for retinal function that is used clinically to correct vitamin A deficiency. Vitamin E An antioxidant vitamin used in many skin creams and multivitamin preparations. Lipoic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Masoprocol Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Pramipexole A non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). Nitric Oxide A vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates. Allopurinol A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Dimethyl sulfoxide A reversible mitogen-activated extracellular signal-regulated kinase-1 (MEK1) and MEK2 inhibitor used to treat certain types of melanoma, metastatic non-small cell lung cancer, and locally advanced or metastatic anaplastic thyroid cancer. Probucol Used to lower LDL and HDL cholesterol. 3,4-Dihydroxycinnamic Acid Not Available Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). 3-hydroxyanthranilic acid An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. Dihydrolipoic Acid Not Available p-Coumaric acid Not Available Quercetin Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. AEOL 10150 Investigated for use/treatment in amyotrophic lateral sclerosis (ALS). Transcrocetinate Investigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes. Acetylcysteine A medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. Nicaraven Investigated for use/treatment in cerebrovascular disease (unspecified). Lodoxamide An ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. Ferulic acid Not Available Uric acid At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke. Idebenone An analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON). Chromic chloride A supplement to intravenous solutions given for total parenteral nutrition (TPN). Thiosulfuric acid A sulfur donor used for sequential use with sodium nitrite for the reversal of acute cyanide poisoning that is judged to be life-threatening. Mequinol A topical agent used in combination with tretinoin to treat solar lentigines. Hydroquinone A topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. Selenic acid An ingredient found in a variety of supplements and vitamins. Selenium An ingredient found in a variety of supplements and vitamins. Lycopene An ingredient found in a variety of supplements and vitamins. Tocopherol Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and... Rebamipide Rebamipide has been investigated for the treatment of Stomach Ulcer, Keratoconjunctivitis Sicca, and Gastric Adenoma and Early Gastric Cancer. Allicin Allicin has been used in trials studying the treatment of Follicular Lymphoma. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Epigallocatechin gallate Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. Bucillamine Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis. Edaravone A free radical scavenger used to delay the progression of ALS. Tempol Tempol has been used in trials studying the treatment of Anal Cancer. Propyl Gallate Propyl Gallate is under investigation in clinical trial NCT01450098 (A Study of LY2484595 in Healthy Subjects). Apocynin Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease. Tocotrienol Tocotrienol has been investigated for the treatment of Cholesterol Lowering. Hydroxytyrosol Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer. Acteoside Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy). Tirilazad Tirilazad has been used in trials studying the treatment of Spinal Cord Injury. Chromanol Chromanol has been used in trials studying the treatment of Prostate Cancer. alpha-Tocopherol succinate A form of vitamin E used to treat and prevent vitamin deficiencies. alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. Sodium bisulfite Sodium bisulfite has been used externally for parasitic skin diseases and as gastrointestinal antiseptic. Tocopherylquinone Not Annotated N,N'-diphenyl-1,4-phenylenediamine Not Annotated 4-(Isopropylamino)diphenylamine 4-(Isopropylamino)diphenylamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Turmeric Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Calcium ascorbate Not Available Kojic acid Not Available Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Dexpramipexole Dexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of... gamma-Tocopherol gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. 2,5-di-tert-butylhydroquinone Not Available Cyclo(his-pro) Not Available Tricetin Not Available Bisphenol A Not Available t-Butylhydroquinone Not Available Droloxifene Not Annotated Maritime pine extract Not Annotated Garlic oil Not Annotated Baicalein Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of... Silibinin Currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning. Vitis vinifera seed Not Annotated
- Drugs & Drug Targets