Chromic chloride

Identification

Summary

Chromic chloride is a supplement to intravenous solutions given for total parenteral nutrition (TPN).

Brand Names
Multitrace-4, Multitrace-5
Generic Name
Chromic chloride
DrugBank Accession Number
DB09129
Background

Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 158.355
Monoisotopic: 156.847070025
Chemical Formula
Cl3Cr
Synonyms
  • anhydrous chromium(III) chloride
  • Chromium chloride
  • Chromium trichloride
  • chromium(3+) trichloride
  • Chromium(III) chloride
  • Puratronic chromium chloride
  • Trichlorochromium

Pharmacology

Indication

For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

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Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Providing chromium during TPN helps prevent deficiency symptoms including impaired glucose tolerance, ataxia, peripheral neuropathy and a confusional state similar to mild/moderate hepatic encephalopathy.

Mechanism of action

Metallic chromium has no biological activity. Chromium is referred as a glucose tolerance factor. This glucose tolerance factor is a complex of molecules. Glycine, cysteine, glutamic acid and nicotinic acid along with chromium form this complex.

TargetActionsOrganism
AInsulin receptor
activator
Humans
Absorption

Chromium absorption can increase with exercise.

Volume of distribution

Chromium is stored in liver, spleen, soft tissue and bone.

Protein binding

Chromic chloride-induced binding of protein to red cells.

Metabolism

The metabolism of chromic chloride hexahydrate in guinea pigs for 60 days after intratracheal injection of 200 ug Cr 10 min after injection, 69% of the dose remained in the lungs, & only 4% was found in the blood & liver, kidneys, spleen. By 24 hr, 45% was still in the lungs, 6% was excreted in the urine, & only a very small % was found in the other tissues. The spleen was the only tissue that showed accumulation & that occurred during the 1st 48 hr.

Route of elimination

Most absorbed chromium is excreted rapidly in the urine, whereas unabsorbed chromium is excreted through feces.

Half-life

31- 41 hours

Clearance

Not Available

Adverse Effects
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Toxicity

Reported toxic reactions to chromium include nausea, vomiting, ulcers of the gastrointestinal tract, renal and hepatic damage, convulsions and coma. The acute LD50 for intravenous trivalent chromium in rats was reported as 10 to 18 mg/kg.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Chromic chloride which could result in a lower serum level and potentially a reduction in efficacy.
Food Interactions
  • Administer vitamin supplements. Niacin (from food or supplements) may increase the absorption of chromium.
  • Take with foods containing vitamin C. Vitamin C may increase the oral absorption of chromium/chromic chloride.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Chromic chloride hexahydrateKB1PCR9DMW10060-12-5LJAOOBNHPFKCDR-UHFFFAOYSA-K
Active Moieties
NameKindUNIICASInChI Key
Chromic cationionicX1N4508KF116065-83-1BFGKITSFLPAWGI-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Chromic ChlorideInjection, solution20.5 ug/1mLIntravenousAmerican Regent1990-09-302012-04-01US flag
ChromiumInjection, solution4 ug/1mLIntravenousHospira, Inc.2016-04-27Not applicableUS flag
Chromium Chromic ChlorideInjection, solution4 ug/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2019-10-18Not applicableUS flag
Micro CRSolution4 mcg / mLIntravenousSandoz Canada Incorporated1993-12-31Not applicableCanada flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ActichromTablet200 mcgOralNutraceutical CorporationNot applicableNot applicableCanada flag
Chromatone - Tab 100mcgTablet100 mcgOralAbundance Naturally Ltd1996-08-292009-07-23Canada flag
Chromium Gtf Tab 500mcgTablet500 mcgOralVita Health Products Inc1995-12-312009-08-06Canada flag
Formula L.L.Capsule75 mcg / capOralNutrition For Life International1998-11-301999-08-11Canada flag
Gtf ChromiumTablet200 mcgOralSeroyal International Inc.1988-12-312009-07-06Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ADDAMEL INFUSION NChromic chloride hexahydrate (53.3 mcg) + Cupric chloride dihydrate (3.4 mg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Potassium Iodide (166 mcg) + Sodium selenite pentahydrate (105 mcg) + Sodium fluoride (2.1 mg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg)Solution, concentrateIntravenousFRESENIUS KABI COLOMBIA S.A.S.2006-11-102009-05-08Colombia flag
ADDAMEL NChromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (0.1 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (19.8 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium selenite (17.3 mcg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1.05 mg/ml)Injection, solution, concentrateIntravenousFresenius Kabi Italia S.R.L.2014-07-082020-05-12Italy flag
ADDAMEL N FOR INFUSIONChromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (0.34 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (99 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium selenite (6.9 mcg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1.36 mg/ml)InjectionIntravenousFRESENIUS KABI (SINGAPORE) PTE LTD1992-01-31Not applicableSingapore flag
ADDAVEN CONCENTRATE FOR SOLUTION FOR INFUSIONChromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (102.3 mcg/ml) + Ferric chloride hexahydrate (540 mcg/ml) + Manganese chloride tetrahydrate (19.79 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium selenite (17.29 mcg/ml) + Sodium fluoride (210 mcg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1050 mcg/ml)SolutionIntravenousFRESENIUS KABI (SINGAPORE) PTE LTD2017-07-24Not applicableSingapore flag
Addaven Konzentrat zur Herstellung einer InfusionslösungChromic chloride hexahydrate (5.33 μg/ml) + Cupric chloride dihydrate (0.1 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (19.8 μg/ml) + Potassium Iodide (16.6 μg/ml) + Sodium selenite (17.3 μg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 μg/ml) + Zinc chloride (1.05 mg/ml)Injection, solution, concentrateIntravenousFresenius Kabi Austria Gmb H2015-03-02Not applicableAustria flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Addamel NChromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Manganese chloride tetrahydrate (0.027 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2013-05-072017-03-31US flag
ADDAMEL N 20 AMPULChromic chloride (53.3 mcg/10mL) + Cupric Chloride (3.4 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (990 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (69 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL)Injection, solutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2019-04-30Not applicableTurkey flag
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYONChromic chloride (53.3 mcg/10mL) + Cupric Chloride (1.02 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (198 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (173 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL)Injection, solutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2016-09-062022-11-10Turkey flag
Chromic ChlorideChromic chloride hexahydrate (20.5 ug/1mL)Injection, solutionIntravenousAmerican Regent1990-09-302012-04-01US flag
Megavite RxChromic chloride hexahydrate (0.1 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (27 mg/1) + Folic acid (1 mg/1) + Lemon (50 mg/1) + Magnesium oxide (50 mg/1) + Manganese (5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine Se-75 (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1)Tablet, film coatedOralBreckenridge Pharmaceutical, Inc.2009-06-012010-03-31US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal salts
Sub Class
Transition metal chlorides
Direct Parent
Transition metal chlorides
Alternative Parents
Inorganic chloride salts
Substituents
Inorganic chloride salt / Inorganic salt / Transition metal chloride
Molecular Framework
Not Available
External Descriptors
chromium chloride (CHEBI:53351)
Affected organisms
Not Available

Chemical Identifiers

UNII
Z310X5O5RP
CAS number
10025-73-7
InChI Key
QSWDMMVNRMROPK-UHFFFAOYSA-K
InChI
InChI=1S/3ClH.Cr/h3*1H;/q;;;+3/p-3
IUPAC Name
chromium(3+) ion trichloride
SMILES
[Cl-].[Cl-].[Cl-].[Cr+3]

References

General References
  1. Pubchem [Link]
  2. ChemIDplus [Link]
  3. DAILYMED [Link]
PubChem Compound
6452300
PubChem Substance
310265044
ChemSpider
23193
RxNav
21009
ChEBI
53351
Wikipedia
Chromium(III)_chloride

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedPreventionDeficiency, Vitamin D / Pre-Eclampsia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Solution, concentrateIntravenous
InjectionIntravenous5.33 mcg/ml
Injection, solutionIntravenous drip
SolutionIntravenous5.33 mcg/ml
TabletOral100 mcg
CapsuleOral
Injection, solutionIntravenous20.5 ug/1mL
Injection, solutionIntravenous4 ug/1mL
TabletOral500 mcg
Tablet, coatedOral
CapsuleOral75 mcg / cap
TabletOral200 mcg
CapsuleOral200 mcg / cap
Tablet, film coatedOral
SolutionIntravenous4 mcg / mL
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
LiquidOral100 mcg / 15 mL
SolutionIntravenous0.053 mg/10ml
LiquidOral
TabletOral100 mcg / tab
TabletOral
SolutionOral200 mcg / 15 mL
LiquidOral150 mcg / 15 mL
LiquidIntravenous
SolutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility5.83 mg/mLALOGPS
logP2.09ALOGPS
logP0.61Chemaxon
logS-1.4ALOGPS
pKa (Strongest Acidic)-7Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity5.62 m3·mol-1Chemaxon
Polarizability2.39 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Activator
General Function
Receptor signaling protein tyrosine kinase activity
Specific Function
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (...
Gene Name
INSR
Uniprot ID
P06213
Uniprot Name
Insulin receptor
Molecular Weight
156331.465 Da
References
  1. Pubchem [Link]

Drug created at September 29, 2015 17:05 / Updated at March 29, 2024 03:23