Chromic chloride

Identification

Name
Chromic chloride
Accession Number
DB09129
Description

Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 158.355
Monoisotopic: 156.847070025
Chemical Formula
Cl3Cr
Synonyms
  • anhydrous chromium(III) chloride
  • Chromium chloride
  • Chromium trichloride
  • chromium(3+) trichloride
  • Chromium(III) chloride
  • Puratronic chromium chloride
  • Trichlorochromium

Pharmacology

Indication

For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Providing chromium during TPN helps prevent deficiency symptoms including impaired glucose tolerance, ataxia, peripheral neuropathy and a confusional state similar to mild/moderate hepatic encephalopathy.

Mechanism of action

Metallic chromium has no biological activity. Chromium is referred as a glucose tolerance factor. This glucose tolerance factor is a complex of molecules. Glycine, cysteine, glutamic acid and nicotinic acid along with chromium form this complex.

TargetActionsOrganism
AInsulin receptor
activator
Humans
Absorption

Chromium absorption can increase with exercise.

Volume of distribution

Chromium is stored in liver, spleen, soft tissue and bone.

Protein binding

Chromic chloride-induced binding of protein to red cells.

Metabolism

The metabolism of chromic chloride hexahydrate in guinea pigs for 60 days after intratracheal injection of 200 ug Cr 10 min after injection, 69% of the dose remained in the lungs, & only 4% was found in the blood & liver, kidneys, spleen. By 24 hr, 45% was still in the lungs, 6% was excreted in the urine, & only a very small % was found in the other tissues. The spleen was the only tissue that showed accumulation & that occurred during the 1st 48 hr.

Route of elimination

Most absorbed chromium is excreted rapidly in the urine, whereas unabsorbed chromium is excreted through feces.

Half-life

31- 41 hours

Clearance
Not Available
Adverse Effects
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Toxicity

Reported toxic reactions to chromium include nausea, vomiting, ulcers of the gastrointestinal tract, renal and hepatic damage, convulsions and coma. The acute LD50 for intravenous trivalent chromium in rats was reported as 10 to 18 mg/kg.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcarboseAcarbose may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Chromic chloride which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AclidiniumAclidinium may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
AcrivastineChromic chloride may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
Additional Data Available
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  • Severity
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  • Evidence Level
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Food Interactions
  • Administer vitamin supplements. Niacin (from food or supplements) may increase the absorption of chromium.
  • Take with foods containing vitamin C. Vitamin C may increase the oral absorption of chromium/chromic chloride.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Chromic chloride hexahydrateKB1PCR9DMW10060-12-5LJAOOBNHPFKCDR-UHFFFAOYSA-K
Active Moieties
NameKindUNIICASInChI Key
Chromic cationionicX1N4508KF116065-83-1BFGKITSFLPAWGI-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Chromic ChlorideInjection, solution20.5 ug/1mLIntravenousAmerican Regent1990-09-302012-04-01US flag
ChromiumInjection, solution4 ug/1mLIntravenousHospira, Inc.2016-04-27Not applicableUS flag
Chromium Chromic ChlorideInjection, solution4 ug/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2019-10-18Not applicableUS flag
Micro CRSolutionIntravenousSandoz Canada Incorporated1993-12-31Not applicableCanada flag
Additional Data Available
  • Application Number
    Application Number
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    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ActichromTabletOralNutraceutical CorporationNot applicableNot applicableCanada flag
Chromatone - Tab 100mcgTabletOralAbundance Naturally Ltd1996-08-292009-07-23Canada flag
Chromium Gtf Tab 500mcgTabletOralVita Health Products Inc1995-12-312009-08-06Canada flag
Formula L.L.CapsuleOralNutrition For Life International1998-11-301999-08-11Canada flag
Gtf ChromiumTabletOralSeroyal International Inc.1988-12-312009-07-06Canada flag
Image CapsCapsuleOralNew Vision Nutritionals Company1999-04-012002-11-20Canada flag
Nl 99LiquidOralAbundance Naturally Ltd2002-12-102006-06-16Canada flag
P.E. 99 - Tab 100mcgTabletOralAbundance Naturally Ltd1996-09-051999-08-06Canada flag
S.S. FormulaSolutionOralNutrican Nutritionals Ltd.1999-12-132009-02-04Canada flag
Tlns FormulaLiquidOralChanges International2002-02-222005-08-24Canada flag
Additional Data Available
  • Application Number
    Application Number
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    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AddnutrivChromic chloride (10 mcg) + Cupric Chloride (380 mcg) + Ferric chloride (1100 mcg) + Manganese (55 mcg) + Potassium Iodide (130 mcg) + Sodium selenite (79 mcg) + Sodium fluoride (950 mcg) + Sodium molybdate (19 mcg) + Zinc (5000 mcg)SolutionIntravenousFresenius KabiNot applicableNot applicableCanada flag
Alkadrenergy TabletsChromic chloride (5 mcg) + Ascorbic acid (60 mg) + Beta carotene (2500 unit) + Biotin (150 mcg) + Calcium (50 mg) + Choline (100 mg) + Cyanocobalamin (45 mcg) + Folic acid (0.2 mg) + Inositol (25 mg) + Iodine (0.1 mg) + Magnesium (50 mg) + Manganese (0.5 mg) + Molybdenum (3 mcg) + Nicotinamide (40 mg) + Pantothenic acid (15 mg) + Pyridoxine hydrochloride (6.25 mg) + Riboflavin (6.25 mg) + Sodium selenite (37.5 mcg) + Thiamine (6.25 mg) + Zinc (9 mg) + alpha-Tocopherol acetate (15 unit)TabletOralMorter HealthsystemNot applicableNot applicableCanada flag
Children's Chewable TabChromic chloride (2.2 mcg) + Ascorbic acid (33.33 mg) + Beta carotene (333.3 unit) + Biotin (33 mcg) + Cyanocobalamin (7.33 mcg) + Folic acid (.1 mg) + Magnesium (23.33 mg) + Manganese sulfate (1.82 mg) + Molybdenum (.7 mcg) + Niacin (.33 mg) + Nicotinamide (2.66 mg) + Calcium pantothenate (5 mg) + Potassium (9.44 mg) + Potassium Iodide (.016 mg) + Pyridoxine hydrochloride (1.66 mg) + Racemethionine (2.66 mg) + Riboflavin (1 mg) + Sodium selenite (2.6 mcg) + Thiamine mononitrate (1.66 mg) + Vitamin A palmitate (333.3 unit) + Zinc (.95 mg) + alpha-Tocopherol succinate (15 unit)TabletOralNf Formulas Inc.1988-12-312000-06-21Canada flag
ChromemateChromic chloride (150 mcg) + Niacin (6 mg)CapsuleOralPuresource Inc.1999-10-152005-08-11Canada flag
Formula CwChromic chloride (25 mcg) + Ascorbic acid (150 mg) + Beta carotene (2500 unit) + Magnesium (50 mg) + Methionine (25 mg) + Niacin (50 mg) + Nicotinamide (50 mg) + Vitamin E (100 unit)TabletOralBody Wise International LlcNot applicableNot applicableCanada flag
Formula Cw-capletChromic chloride (25 mcg) + Ascorbic acid (150 mg) + Beta carotene (2500 unit) + Magnesium (50 mg) + Methionine (25 mg) + Niacin (50 mg) + Nicotinamide (50 mg) + Vitamin E (50 unit)TabletOralBody Wise International Llc1995-12-312005-10-24Canada flag
Fusion Activator Formula TabChromic chloride (8 mcg) + Ascorbic acid (60 mg) + Beta carotene (2500 unit) + Calcium (100 mg) + Cyanocobalamin (9 mcg) + Magnesium (60 mg) + Niacin (10 mg) + Calcium pantothenate (10 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (20 mg)TabletOralL & S Research Corporation1993-12-311996-09-09Canada flag
Great Day/am Formula TabChromic chloride (100 mcg) + Ascorbic acid (125 mg) + Beta carotene (3 mg) + Biotin (75 mcg) + Copper (1 mg) + Cyanocobalamin (6 mcg) + Folic acid (200 mcg) + Iodine (75 mcg) + Manganese (2.5 mg) + Nicotinamide (10 mg) + Pantothenic acid (10 mg) + Potassium (49.5 mg) + Pyridoxine (12.5 mg) + Riboflavin (7.5 mg) + Selenium (50 mcg) + Thiamine (7.5 mg) + Vitamin A palmitate (2500 unit) + Vitamin D (200 unit) + Vitamin E (100 unit) + Zinc (7.5 mg)TabletOralNikken Usa, Incorporated1995-12-312002-06-26Canada flag
High Potency Multivitamins & Minerals CapletsChromic chloride (50 mcg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium phosphate, dibasic (125 mg) + Cholecalciferol (400 unit) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium (55 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (50 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Sodium selenate (50 mcg) + Silicon (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Stannous chloride (0.01 mg) + Thiamine mononitrate (3 mg) + Vitamin A (3500 unit) + Zinc (20 mg) + alpha-Tocopherol acetate (50 unit)TabletOralAshbury Research CorporationNot applicableNot applicableCanada flag
M T E 4 Concentrate InjChromic chloride (10 mcg) + Copper (1 mg) + Manganese (.5 mg) + Zinc (5 mg)LiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1987-12-311997-08-14Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Addamel NChromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Manganese chloride tetrahydrate (0.027 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2013-05-072017-03-31US flag
Chromic ChlorideChromic chloride hexahydrate (20.5 ug/1mL)Injection, solutionIntravenousAmerican Regent1990-09-302012-04-01US flag
Megavite RxChromic chloride hexahydrate (0.1 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (27 mg/1) + Folic acid (1 mg/1) + Lemon (50 mg/1) + Magnesium oxide (50 mg/1) + Manganese (5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine Se-75 (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1)Tablet, film coatedOralBreckenridge Pharmaceutical, Inc.2009-06-012010-03-31US flag
Multitrace -4Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-11-29Not applicableUS flag
Multitrace -4Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-07Not applicableUS flag
Multitrace -4 PediatricChromic chloride hexahydrate (5.12 ug/1mL) + Cupric sulfate pentahydrate (0.4 mg/1mL) + Manganese sulfate (77 ug/1mL) + Zinc sulfate heptahydrate (4.39 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-09Not applicableUS flag
Multitrace-4Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL) + Zinc sulfate heptahydrate (4.39 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1994-02-17Not applicableUS flag
Multitrace-4 NeonatalChromic chloride hexahydrate (4.36 ug/1mL) + Cupric sulfate pentahydrate (0.39 mg/1mL) + Manganese sulfate (77 mg/1mL) + Zinc sulfate heptahydrate (6.6 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1990-09-30Not applicableUS flag
Multitrace-5Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Selenious acid (98 ug/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-09-14Not applicableUS flag
Multitrace-5Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL) + Selenious acid (32.7 ug/1mL) + Zinc sulfate heptahydrate (4.39 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1994-02-17Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal salts
Sub Class
Transition metal chlorides
Direct Parent
Transition metal chlorides
Alternative Parents
Inorganic chloride salts
Substituents
Inorganic chloride salt / Inorganic salt / Transition metal chloride
Molecular Framework
Not Available
External Descriptors
chromium chloride (CHEBI:53351)

Chemical Identifiers

UNII
Z310X5O5RP
CAS number
10025-73-7
InChI Key
QSWDMMVNRMROPK-UHFFFAOYSA-K
InChI
InChI=1S/3ClH.Cr/h3*1H;/q;;;+3/p-3
IUPAC Name
chromium(3+) ion trichloride
SMILES
[Cl-].[Cl-].[Cl-].[Cr+3]

References

General References
  1. Pubchem [Link]
  2. ChemIDplus [Link]
  3. DAILYMED [Link]
PubChem Compound
6452300
PubChem Substance
310265044
ChemSpider
23193
RxNav
21009
ChEBI
53351
Wikipedia
Chromium(III)_chloride
AHFS Codes
  • 88:29.00* — Minerals
  • 88:28.00 — Multivitamin Preparations
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedPreventionDeficiency, Vitamin D / Prophylaxis of preeclampsia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solution, concentrateIntravenous6.9 mcg/mL
Injection, solutionIntravenous53.3 mcg/10mL
Injection, solutionIntravenous drip166 mcg/10ml
Injection, solution, concentrateIntravenous17.3 μg/ml
CapsuleOral
Injection, solutionIntravenous20.5 ug/1mL
Injection, solutionIntravenous4 ug/1mL
TabletOral
Tablet, coatedOral
SolutionIntravenous2 mg
CapsuleOral
SolutionIntravenous
Tablet, film coatedOral
SolutionIntravenous
LiquidIntravenous
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
Solution, concentrateIntravenous53.3 mcg
Injection, solution, concentrateIntravenous44.569 mg
LiquidOral
TabletOral
SolutionOral
Solution, concentrateIntravenous30.45 mcg
LiquidOral
Injection, solution, concentrateIntravenous695.8 mcg/ml
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility5.83 mg/mLALOGPS
logP2.09ALOGPS
logP0.61ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)-7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity5.62 m3·mol-1ChemAxon
Polarizability2.39 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Activator
General Function
Receptor signaling protein tyrosine kinase activity
Specific Function
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (...
Gene Name
INSR
Uniprot ID
P06213
Uniprot Name
Insulin receptor
Molecular Weight
156331.465 Da
References
  1. Pubchem [Link]

Drug created on September 29, 2015 11:05 / Updated on November 30, 2020 13:38

Repurpose 1