Name
Butyrates
Accession Number
DBCAT000425
Description

4-carbon acids, salts, and derivatives of BUTYRIC ACID.

Drugs
DrugDrug Description
BaclofenA GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
ClofibrateA fibric acid derivative used to treat hypertriglyceridemia and high cholesterol.
ProgabideIndicated for the treatment of epilepsy.
GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
VigabatrinAn irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
gamma-Hydroxybutyric acidUsed as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
Isobutyric acidNot Available
CanalineNot Available
2-aminoisobutyric acidNot Available
N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acidN(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar.
Butyric AcidA four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
L-2,4-diaminobutyric acidNot Available
L-2-amino-3-butynoic acidNot Available
Alpha-Aminobutyric AcidNot Available
BL-1020Investigated for use/treatment in schizophrenia and schizoaffective disorders.
BendamustineAn antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
Gabapentin enacarbilA gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
TeriflunomideA pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis.
Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
EtofibrateEtofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.
CiprofibrateNot Annotated
Sodium oxybateA central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
SacubitrilA neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
PD-217014PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome.
PivagabinePivagabine has been used in trials studying the treatment of Stress and Anxiety.
SimfibrateNot Annotated
PrethcamideNot Annotated
PhenibutNot Annotated
ClofibrideNot Annotated
Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
Hopantenic acidHopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal...
SacubitrilatA metabolite of LCZ696 with neprilysin inhibitory activity.
gamma-Aminobutyric acidThe most common inhibitory neurotransmitter in the central nervous system.
Gamma-amino-beta-hydroxybutyric acidAn anticonvulsant indicated to treat convulsions in children and epilepsy.
FirsocostatFirsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)).
Drugs & Drug Targets
DrugTargetType
BaclofenGamma-aminobutyric acid type B receptor subunit 1target
BaclofenGamma-aminobutyric acid type B receptor subunit 2target
PregabalinExcitatory amino acid transporter 3transporter
PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
PregabalinLarge neutral amino acids transporter small subunit 1transporter
ClofibratePeroxisome proliferator-activated receptor alphatarget
ClofibrateCytochrome P450 3A4enzyme
ClofibrateGlutathione S-transferase A2enzyme
ClofibrateCytochrome P450 2E1enzyme
ClofibrateCytochrome P450 1A1enzyme
ClofibrateCytochrome P450 4A11enzyme
ClofibrateThyroxine-binding globulincarrier
ProgabideGamma-aminobutyric acid receptor subunit alpha-1target
ProgabideGamma-aminobutyric acid type B receptor subunit 1target
GabapentinAdenosine receptor A1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
GabapentinLarge neutral amino acids transporter small subunit 1transporter
GabapentinVoltage-dependent N-type calcium channeltarget
GabapentinPotassium voltage-gated channel subfamily KQT member 3target
GabapentinPotassium voltage-gated channel subfamily KQT member 5target
FenofibratePeroxisome proliferator-activated receptor alphatarget
FenofibrateMatrix metalloproteinase-25target
FenofibrateCytochrome P450 2C8enzyme
FenofibrateCytochrome P450 2C9enzyme
FenofibrateNuclear receptor subfamily 1 group I member 2target
FenofibrateUDP-glucuronosyltransferase 1-9enzyme
FenofibrateBile salt export pumptransporter
FenofibrateSerum albumincarrier
FenofibrateCytochrome P450 2C19enzyme
FenofibrateCytochrome P450 2A6enzyme
FenofibrateLiver carboxylesterase 1enzyme
FenofibrateCarbonyl reductase [NADPH] 1enzyme
FenofibrateAldo-keto reductase family 1 member C1enzyme
FenofibrateAldo-keto reductase family 1 member C2enzyme
FenofibrateAldo-keto reductase family 1 member C3enzyme
FenofibrateAldose reductaseenzyme
Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
VigabatrinProton-coupled amino acid transporter 1transporter
VigabatrinCytochrome P450 2C9enzyme
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
BezafibratePeroxisome proliferator-activated receptor alphatarget
BezafibrateSolute carrier organic anion transporter family member 1B1transporter
BezafibratePeroxisome proliferator-activated receptor deltatarget
BezafibratePeroxisome proliferator-activated receptor gammatarget
BezafibrateCytochrome P450 1A1enzyme
BezafibrateCytochrome P450 2C8enzyme
BezafibrateCytochrome P450 3A4enzyme
BezafibrateNuclear receptor subfamily 1 group I member 2target
BezafibrateRetinoic acid receptor RXR-alphatarget
BezafibrateRetinoic acid receptor RXR-betatarget
BezafibrateRetinoic acid receptor RXR-gammatarget
gamma-Hydroxybutyric acidMonocarboxylate transporter 2transporter
gamma-Hydroxybutyric acidMonocarboxylate transporter 1transporter
gamma-Hydroxybutyric acidMonocarboxylate transporter 4transporter
gamma-Hydroxybutyric acidGamma-hydroxybutyrate (GHB) receptortarget
gamma-Hydroxybutyric acidGamma-aminobutyric acid receptor subunit beta-1target
Isobutyric acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
CanalineOrnithine aminotransferase, mitochondrialtarget
2-aminoisobutyric acidCorticoliberintarget
2-aminoisobutyric acidPro-neuropeptide Ytarget
2-aminoisobutyric acidMonocarboxylate transporter 10transporter
Butyric Acid(S)-2-haloacid dehalogenasetarget
Butyric AcidCholinesterasetarget
Butyric Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Butyric AcidCholinesteraseenzyme
L-2,4-diaminobutyric acidEnvelope glycoprotein gp160target
L-2-amino-3-butynoic acidCysteine desulfurasetarget
L-2-amino-3-butynoic acidCystathionine gamma-lyasetarget
Alpha-Aminobutyric AcidGlycine amidinotransferase, mitochondrialtarget
Alpha-Aminobutyric AcidGag-Pol polyproteintarget
Alpha-Aminobutyric AcidPro-epidermal growth factortarget
Alpha-Aminobutyric AcidLantibiotic mersacidintarget
BL-1020Dopamine D2 receptortarget
BL-10205-hydroxytryptamine receptor 2Atarget
BendamustineCytochrome P450 1A2enzyme
Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-1target
Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-2target
Gabapentin enacarbilSodium-coupled monocarboxylate transporter 1transporter
Gabapentin enacarbilSodium-dependent multivitamin transportertransporter
TeriflunomideATP-binding cassette sub-family G member 2transporter
TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
TeriflunomideCytochrome P450 2C8enzyme
TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
TeriflunomideCytochrome P450 1A2enzyme
Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
CiprofibratePeroxisome proliferator-activated receptor alphatarget
Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
SacubitrilNeprilysintarget
SacubitrilSolute carrier organic anion transporter family member 1B1transporter
SacubitrilSolute carrier organic anion transporter family member 1B3transporter
Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
Fenofibric acidMatrix metalloproteinase-25target
Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
Fenofibric acidNuclear receptor subfamily 1 group I member 2target
gamma-Aminobutyric acidGlycine amidinotransferase, mitochondrialtarget
gamma-Aminobutyric acidProton-coupled amino acid transporter 1transporter
gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 1target
gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 2target