GABA Agonists

Name
GABA Agonists
Accession Number
DBCAT000427
Description

Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).

Drugs
DrugDrug Description
ABP-700ABP-700 is under investigation in clinical trial NCT02800590 (Study to Investigate the Safety and Efficacy of 3 Dosing Regimens of ABP-700 for Procedural Sedation in Adult Participants Undergoing Colonoscopy).
AdipiplonInvestigated for use/treatment in insomnia and sleep disorders.
Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
AZD 3355Investigated for use/treatment in gastroesophageal reflux disease (GERD).
BaclofenA GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
GaboxadolInvestigated for use/treatment in sleep disorders and insomnia.
LesogaberanLesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others.
MuscimolMuscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease.
PhenibutNot Annotated
ProgabideIndicated for the treatment of epilepsy.
TramiprosateInvestigated for use/treatment in strokes and alzheimer's disease.
ZaleplonA sedative used for short term treatment of insomnia in adults.
ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
Drugs & Drug Targets
DrugTargetType
ABP-700GABA(A) Receptortarget
AdipiplonGamma-aminobutyric acid receptor subunit alpha-3target
AdipiplonGABA(A) Receptor Benzodiazepine Binding Sitetarget
Arbaclofen PlacarbilGamma-aminobutyric acid receptor subunit gamma-3target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
AZD 3355Gamma-aminobutyric acid type B receptor subunit 2target
AZD 3355Gamma-aminobutyric acid type B receptor subunit 1target
AZD 3355Cellular tumor antigen p53target
BaclofenGamma-aminobutyric acid type B receptor subunit 1target
BaclofenC-X-C chemokine receptor type 4target
BaclofenGamma-aminobutyric acid type B receptor subunit 2target
ClobazamCytochrome P450 2D6enzyme
ClobazamGamma-aminobutyric acid receptor subunit gamma-3target
ClobazamGABA(A) Receptortarget
ClobazamATP-dependent translocase ABCB1transporter
ClobazamCytochrome P450 2C18enzyme
ClobazamGamma-aminobutyric acid receptor subunit alpha-1target
ClobazamCytochrome P450 3A7enzyme
ClobazamCytochrome P450 3A5enzyme
ClobazamCytochrome P450 2B6enzyme
ClobazamCytochrome P450 2C8enzyme
ClobazamCytochrome P450 1A2enzyme
ClobazamUDP-glucuronosyltransferase 1A1enzyme
ClobazamUDP-glucuronosyltransferase 2B4enzyme
ClobazamCytochrome P450 3A4enzyme
ClobazamCytochrome P450 2C19enzyme
ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClobazamUDP-glucuronosyltransferase 1A6enzyme
ClobazamAlbumincarrier
ClobazamAlpha-1-acid glycoprotein 1carrier
ClobazamCytochrome P450 2C9enzyme
ClobazamUDP-glucuronosyltransferase 1A4enzyme
GaboxadolProton-coupled amino acid transporter 1transporter
GaboxadolGamma-aminobutyric acid receptor subunit deltatarget
LesogaberanGamma-aminobutyric acid type B receptor subunit 2target
LesogaberanGamma-aminobutyric acid type B receptor subunit 1target
MuscimolGamma-aminobutyric acid receptor subunit gamma-2target
MuscimolGamma-aminobutyric acid receptor subunit alpha-1target
MuscimolGamma-aminobutyric acid receptor subunit beta-3target
PhenibutSodium/Potassium Transporting ATPasetarget
PhenibutGABA(B) Receptortarget
Phenibut4-aminobutyrate aminotransferase, mitochondrialenzyme
ProgabideGamma-aminobutyric acid type B receptor subunit 2target
ProgabideGamma-aminobutyric acid type B receptor subunit 1target
ProgabideGamma-aminobutyric acid receptor subunit alpha-1target
TramiprosateAmyloid-beta precursor proteintarget
ZaleplonCytochrome P450 3A7enzyme
ZaleplonCytochrome P450 3A5enzyme
ZaleplonAldehyde oxidaseenzyme
ZaleplonCytochrome P450 3A4enzyme
ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 2D6enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 3A4enzyme
ZolpidemCytochrome P450 1A2enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
ZolpidemCytochrome P450 2C9enzyme
ZolpidemCytochrome P450 2C19enzyme
ZolpidemGamma-aminobutyric acid receptor subunit gamma-3target
ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target