Adrenergic beta-Antagonists

Name
Adrenergic beta-Antagonists
Accession Number
DBCAT000456  (DBCAT002187)
Description

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

ATC Classification
Drugs
DrugDrug Description
EsmololA cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension.
BetaxololA cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically).
MetoprololA beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction.
AtenololA synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients.
TimololA non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.
CarteololA beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma.
PropranololA non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.
LabetalolAn alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome.
BisoprololA beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension.
PindololA beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation.
CarvedilolA non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients.
AcebutololA selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults.
NadololA non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension.
LevobunololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
MetipranololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
SotalolA methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter.
NebivololA beta blocking agent used to treat hypertension and aid in the management of heart failure.
AlprenololFor the treatment of hypertension, angina, and arrhythmia
BevantololFor the treatment of angina pectoris and hypertension.
PractololUsed in the emergency treatment of cardiac arrhythmias.
PenbutololA beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents.
OxprenololA non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety.
CeliprololCeliprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
BufuralolBufuralol is a new, non-selective -adrenoceptor blocking agent.
BopindololFor the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
BupranololUsed to manage hypertension and tachycardia. Also used to treat glaucoma.
IndenololIndenolol is a drug of the beta-adrenergic blocker class.
BefunololUsed in the management of open angle glaucoma. PMID: 12480285.
ArotinololArtinolol was introduced to be used as an antihypertensive agent since 1986. It has been studied for other functions like tremor control for patients with Parkinson disease and it is...
TalinololTalinolol has been investigated for the basic science of Gastrointestinal Motility Disorder.
LandiololLandiolol has been used in trials studying the treatment of Pharmacokinetics/Dynamics Study.
BucindololBucindolol has been investigated in Heart Failure.
CloranololNot Annotated
MepindololMepindolol is a 2-methyl derivative of pindolol. It is a beta blocker.
EpanololEpanolol is an beta blocker.
TertatololTertatolol is a beta blocker.
EsatenololEsatenolol is a beta blocker.
PropafenoneA Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias.
LevobetaxololUsed in the treatment of open-angle glaucoma and ocular hypertension [FDA Label].
AnisodamineAnisodamine has been investigated for the treatment of Intestinal Diseases.
DexpropranololNot Available
Drugs & Drug Targets
DrugTargetType
EsmololBeta-1 adrenergic receptortarget
EsmololCytochrome P450 2D6enzyme
BetaxololBeta-1 adrenergic receptortarget
BetaxololBeta-2 adrenergic receptortarget
BetaxololCytochrome P450 1A2enzyme
BetaxololCytochrome P450 2D6enzyme
MetoprololBeta-1 adrenergic receptortarget
MetoprololCytochrome P450 2D6enzyme
MetoprololBeta-2 adrenergic receptortarget
MetoprololSolute carrier family 22 member 2transporter
MetoprololSerum albumincarrier
MetoprololCytochrome P450 3A4enzyme
AtenololBeta-1 adrenergic receptortarget
AtenololBeta-2 adrenergic receptortarget
AtenololCytochrome P450 2D6enzyme
AtenololBile salt export pumptransporter
AtenololSerum albumincarrier
TimololBeta-1 adrenergic receptortarget
TimololBeta-2 adrenergic receptortarget
TimololCytochrome P450 2D6enzyme
TimololP-glycoprotein 1transporter
TimololCytochrome P450 2C19enzyme
TimololLysozymetarget
CarteololBeta-2 adrenergic receptortarget
CarteololBeta-1 adrenergic receptortarget
CarteololCytochrome P450 2D6enzyme
PropranololBeta-1 adrenergic receptortarget
PropranololBeta-2 adrenergic receptortarget
PropranololBeta-3 adrenergic receptortarget
Propranolol5-hydroxytryptamine receptor 1Atarget
Propranolol5-hydroxytryptamine receptor 1Btarget
PropranololCytochrome P450 1A2enzyme
PropranololCytochrome P450 2D6enzyme
PropranololAlpha-1-acid glycoprotein 1carrier
PropranololCytochrome P450 2C19enzyme
PropranololCytochrome P450 3A4enzyme
PropranololCytochrome P450 3A5enzyme
PropranololCytochrome P450 3A7enzyme
PropranololSolute carrier family 22 member 2transporter
PropranololP-glycoprotein 1transporter
PropranololCytochrome P450 1A1enzyme
PropranololAmine oxidase [flavin-containing] Aenzyme
PropranololSerum albumincarrier
LabetalolAlpha-1 adrenergic receptorstarget
LabetalolBeta-1 adrenergic receptortarget
LabetalolBeta-2 adrenergic receptortarget
LabetalolCytochrome P450 2D6enzyme
LabetalolCytochrome P450 2C19enzyme
LabetalolSerum albumincarrier
Labetalolalpha1-acid glycoproteincarrier
LabetalolATP-binding cassette sub-family B member 5transporter
LabetalolUDP-glucuronosyltransferase 1-1enzyme
LabetalolUDP-glucuronosyltransferase 2B7enzyme
LabetalolUDP-glucuronosyltransferase 1-9enzyme
BisoprololBeta-1 adrenergic receptortarget
BisoprololBeta-2 adrenergic receptortarget
BisoprololCytochrome P450 3A4enzyme
BisoprololP-glycoprotein 1transporter
PindololBeta-1 adrenergic receptortarget
PindololBeta-2 adrenergic receptortarget
Pindolol5-hydroxytryptamine receptor 1Atarget
Pindolol5-hydroxytryptamine receptor 1Btarget
PindololCytochrome P450 2D6enzyme
PindololBeta-3 adrenergic receptortarget
CarvedilolAlpha-1A adrenergic receptortarget
CarvedilolBeta-1 adrenergic receptortarget
CarvedilolNADH dehydrogenase [ubiquinone] 1 subunit C2target
CarvedilolBeta-2 adrenergic receptortarget
CarvedilolVascular endothelial growth factor Atarget
CarvedilolNatriuretic peptides Btarget
CarvedilolGap junction alpha-1 proteintarget
CarvedilolPotassium voltage-gated channel subfamily H member 2target
CarvedilolVascular cell adhesion protein 1target
CarvedilolCytochrome P450 2C9enzyme
CarvedilolCytochrome P450 2D6enzyme
CarvedilolXanthine dehydrogenase/oxidaseenzyme
CarvedilolP-glycoprotein 1transporter
CarvedilolCytochrome P450 1A2enzyme
CarvedilolCytochrome P450 3A4enzyme
CarvedilolCytochrome P450 1A1enzyme
CarvedilolCytochrome P450 2E1enzyme
CarvedilolAlpha-1D adrenergic receptortarget
CarvedilolAlpha-1B adrenergic receptortarget
CarvedilolAlpha-2C adrenergic receptortarget
CarvedilolAlpha-2B adrenergic receptortarget
CarvedilolAlpha-2A adrenergic receptortarget
CarvedilolE-selectintarget
CarvedilolHypoxia-inducible factor 1-alphatarget
CarvedilolInward rectifier potassium channel 4target
CarvedilolUDP-glucuronosyltransferase 1-1enzyme
CarvedilolSerum albumincarrier
CarvedilolUDP-glucuronosyltransferase 2B4enzyme
CarvedilolUDP-glucuronosyltransferase 2B7enzyme
CarvedilolInward rectifier potassium channel 2target
CarvedilolAlpha-1 adrenergic receptorstarget
AcebutololBeta-1 adrenergic receptortarget
AcebutololCytochrome P450 2D6enzyme
AcebutololBeta-2 adrenergic receptortarget
AcebutololP-glycoprotein 1transporter
NadololBeta-1 adrenergic receptortarget
NadololBeta-2 adrenergic receptortarget
NadololP-glycoprotein 1transporter
NadololPOU domain, class 2, transcription factor 1transporter
NadololPOU domain, class 2, transcription factor 2transporter
NadololMultidrug and toxin extrusion protein 1transporter
NadololMultidrug and toxin extrusion protein 2transporter
Nadololalpha1-acid glycoproteincarrier
LevobunololBeta-1 adrenergic receptortarget
LevobunololBeta-2 adrenergic receptortarget
LevobunololCytochrome P450 2D6enzyme
MetipranololBeta-1 adrenergic receptortarget
MetipranololBeta-2 adrenergic receptortarget
MetipranololCytochrome P450 2D6enzyme
SotalolPotassium voltage-gated channel subfamily H member 2target
SotalolBeta-1 adrenergic receptortarget
SotalolBeta-2 adrenergic receptortarget
SotalolCytochrome P450 2D6enzyme
NebivololBeta-1 adrenergic receptortarget
NebivololCytochrome P450 2D6enzyme
NebivololBeta-2 adrenergic receptortarget
NebivololCytochrome P450 3A4enzyme
NebivololSerum albumincarrier
NebivololBeta-3 adrenergic receptortarget
NebivololCytochrome P450 2C19enzyme
AlprenololBeta-1 adrenergic receptortarget
AlprenololBeta-2 adrenergic receptortarget
Alprenolol5-hydroxytryptamine receptor 1Atarget
AlprenololCytochrome P450 2D6enzyme
AlprenololBeta-3 adrenergic receptortarget
BevantololBeta-1 adrenergic receptortarget
BevantololBeta-2 adrenergic receptortarget
BevantololAlpha-1A adrenergic receptortarget
BevantololCytochrome P450 2D6enzyme
PractololBeta-1 adrenergic receptortarget
PractololCytochrome P450 2D6enzyme
PenbutololAlpha-1-acid glycoprotein 1carrier
PenbutololBeta-1 adrenergic receptortarget
PenbutololBeta-2 adrenergic receptortarget
Penbutolol5-hydroxytryptamine receptor 1Atarget
Penbutolol5-hydroxytryptamine receptor 1Btarget
PenbutololCytochrome P450 2D6enzyme
OxprenololBeta-1 adrenergic receptortarget
OxprenololBeta-2 adrenergic receptortarget
OxprenololSolute carrier family 22 member 2transporter
OxprenololCytochrome P450 2D6enzyme
OxprenololBeta-3 adrenergic receptortarget
CeliprololBeta-1 adrenergic receptortarget
CeliprololBeta-2 adrenergic receptortarget
CeliprololBeta-3 adrenergic receptortarget
CeliprololAlpha-2A adrenergic receptortarget
CeliprololAlpha-2B adrenergic receptortarget
CeliprololAlpha-2C adrenergic receptortarget
CeliprololCytochrome P450 2D6enzyme
BufuralolCytochrome P450 2D6enzyme
BufuralolBeta adrenergic receptortarget
BopindololBeta-1 adrenergic receptortarget
BopindololBeta-2 adrenergic receptortarget
Bopindolol5-hydroxytryptamine receptor 1Atarget
Bopindolol5-hydroxytryptamine receptor 1Btarget
BopindololBeta-3 adrenergic receptortarget
BopindololCytochrome P450 2D6enzyme
BupranololBeta-1 adrenergic receptortarget
BupranololBeta-2 adrenergic receptortarget
BupranololBeta-3 adrenergic receptortarget
BupranololCytochrome P450 2D6enzyme
IndenololCytochrome P450 2D6enzyme
BefunololBeta-1 adrenergic receptortarget
BefunololBeta-2 adrenergic receptortarget
BefunololCytochrome P450 2D6enzyme
ArotinololBeta-1 adrenergic receptortarget
ArotinololBeta-2 adrenergic receptortarget
ArotinololAlpha-1 adrenergic receptorstarget
ArotinololSerum albumincarrier
ArotinololAlpha-1-acid glycoprotein 1carrier
ArotinololCytochrome P450 2D6enzyme
TalinololCytochrome P450 2D6enzyme
TalinololP-glycoprotein 1transporter
TalinololCanalicular multispecific organic anion transporter 1transporter
LandiololCytochrome P450 2D6enzyme
BucindololCytochrome P450 2D6enzyme
CloranololCytochrome P450 2D6enzyme
MepindololCytochrome P450 2D6enzyme
EpanololCytochrome P450 2D6enzyme
TertatololCytochrome P450 2D6enzyme
EsatenololCytochrome P450 2D6enzyme
PropafenoneSodium channel protein type 5 subunit alphatarget
PropafenonePotassium voltage-gated channel subfamily H member 2target
PropafenoneCytochrome P450 1A2enzyme
PropafenoneCytochrome P450 2D6enzyme
PropafenoneCytochrome P450 3A4enzyme
PropafenoneP-glycoprotein 1transporter
PropafenoneBeta-1 adrenergic receptortarget
PropafenoneBeta-2 adrenergic receptortarget
LevobetaxololBeta-1 adrenergic receptortarget
LevobetaxololCytochrome P450 2D6enzyme
AnisodamineCytochrome P450 2D6enzyme