- Adrenergic Antagonists
- Accession Number
Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.
Drug Drug Description Esmolol A cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension. Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically). Metoprolol A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Dapiprazole Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. Atenolol A synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients. Alfuzosin An alpha-1 adrenergic antagonist used in the management of benign prostatic hypertrophy (BPH). Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Profenamine An antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. Prazosin An alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. Sotalol A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Doxazosin An alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Bisoprolol A beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension. Phentolamine An alpha adrenergic antagonist used to reverse soft tissue anesthesia. Nicergoline For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration. Tamsulosin An alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction. Tolazoline A vasodilator used to treat pulmonary artery anomalies. Alprenolol For the treatment of hypertension, angina, and arrhythmia Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Phenoxybenzamine An alpha adrenergic agonist used to treat pheochromocytoma and episodes of hypertension and sweating. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Bretylium A norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias. Terazosin An alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. Acebutolol A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults. Nadolol A non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension. Levobunolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Bevantolol For the treatment of angina pectoris and hypertension. Practolol Used in the emergency treatment of cardiac arrhythmias. Penbutolol A beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. 1-benzylimidazole 1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity. Celiprolol Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. Silodosin An alpha-1 adrenergic receptor antagonist used to treat symptoms associated with benign prostatic hyperplasia (BPH). Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Bufuralol Bufuralol is a new, non-selective -adrenoceptor blocking agent. Bopindolol For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Bupranolol Used to manage hypertension and tachycardia. Also used to treat glaucoma. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Indenolol Indenolol is a drug of the beta-adrenergic blocker class. Ifenprodil N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... Befunolol Used in the management of open angle glaucoma. PMID: 12480285. Arotinolol Artinolol was introduced to be used as an antihypertensive agent since 1986. It has been studied for other functions like tremor control for patients with Parkinson disease and it is... Moxisylyte By the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either by... Trimazosin Trimazosin is a sympatholytic alpha blocker. Atipamezole For the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Talinolol Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Landiolol Landiolol has been used in trials studying the treatment of Pharmacokinetics/Dynamics Study. Bunazosin Bunazosin has been used in trials studying the treatment of High Blood Pressure. Idazoxan Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder. Urapidil Urapidil has been investigated for the treatment of Hypertension During Pre-Eclampsia. Bucindolol Bucindolol has been investigated in Heart Failure. Dihydroergocristine An ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's. Cloranolol Not Annotated Mepindolol Mepindolol is a 2-methyl derivative of pindolol. It is a beta blocker. Epanolol Epanolol is an beta blocker. Tertatolol Tertatolol is a beta blocker. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Esatenolol Esatenolol is a beta blocker. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Propafenone A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. Levobetaxolol Used in the treatment of open-angle glaucoma and ocular hypertension [FDA Label]. Buflomedil Not Annotated Dutasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) in adult males by inhibiting 5-alpha reductase. Finasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Promazine A phenothiazine used to manage schizophrenia. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Nefazodone An antidepressant used in the treatment of depression. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Trimipramine A tricyclic antidepressant used to treat depression. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Propiverine An antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency. Periciazine A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Ergotamine A alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Dexpropranolol Not Available Guanadrel Used to treat and control hypertension. Guanethidine An antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension. ORM-12741 ORM-12741 has been used in trials studying the basic science and treatment of Alzheimer's Disease. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
- Drugs & Drug Targets