- Adrenergic alpha-Agonists
- Accession Number
Drugs that selectively bind to and activate alpha adrenergic receptors.
Drug Drug Description Midodrine An alpha-adrenergic antagonist used to treat orthostatic hypotension. Brimonidine An alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea. Epinephrine A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. Apraclonidine An alpha adrenergic agonist used to treat raised intraocular pressure. Phenylephrine An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. Norepinephrine A sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. Phenylpropanolamine A sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy. Clonidine An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. Metaraminol For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage Guanabenz An alpha-2 adrenergic agonist used to treat hypertension. Dexmedetomidine An alpha-2 agonist used for sedation during various procedures. Tizanidine An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. Methoxamine An alpha adrenergic agonist used to treat hypotension. Oxymetazoline An alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea. Methyldopa An alpha-2 adrenergic agonist used to treat hypertension. Guanfacine An alpha-2A adrenergic receptor agonist used to treat ADHD. Mephentermine A sympathomimetic agent used in the treatment of hypotension. Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. Xylometazoline A direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds. Naphazoline A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion. Adrafinil Used to relieve excessive sleepiness and inattention in elderly patients. Etilefrine Etilefrine is an adrenergic agonist that appears to interact with beta-2 and some alpha adrenergic receptors. It has been used as a vasoconstrictor agent. Cirazoline Cirazoline acts on a number of α adrenergic receptors. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. It is believed... Synephrine Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer... Racepinephrine A bronchodilator used to treat intermittent asthma. Amitraz Amitraz is a non-systemic acaricide and insecticide. It was generated in 1969 by the Boots Co. in England. Amitraz presents insect repellent effects and hence, it can be used as... Medetomidine Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist.... Xylazine Xylazine is a clonidine analog which acts as an agonist at α2 adrenoceptors. Veterinarians also use xylazine as an emetic, especially in cats. Romifidine Romifidine is a veterinary drug utilized as a sedative primarily in large animals, most frequently horses. It is also used less commonly in a wide variety of other animal species.... Detomidine Used as a large animal sedative, primarily in horses. Rilmenidine Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease. Octopamine Octopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as... Norfenefrine Not Annotated Pseudoephedrine An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis. Ephedrine An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion. Dipivefrin A prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. Droxidopa A medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Ephedra sinica root An alpha and beta-adrenergic agonist used for the management of respiratory conditions related to bronchial asthma, such as wheezing, shortness of breath, and tightness of chest. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Moxonidine For the treatment of mild to moderate essential or primary hypertension . Effective as most first-line antihypertensives when used as monotherapy . DL-Methylephedrine Used as an antitussive and decongestant . Phendimetrazine A sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity. Ergometrine An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Isometheptene Isometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches. Tetryzoline An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations. Etomidate A short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. Bethanidine For the treatment of hypertension. Dobutamine A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. 4-Methoxyamphetamine Not Available 4-Bromo-2,5-dimethoxyphenethylamine Not Available
- Drugs & Drug Targets